卡瑞利珠单抗诱导的反应性皮肤毛细血管内皮细胞增殖与肝癌肿瘤应答相关性研究  

Relationship between carrelizumab-induced reactive cutaneous capillary endothelial proliferation and hepatocellular carcinoma tumor response

作　　者：光琴 刘开才[2] 卢今[1] GUANG Qin;LIU Kai-cai;LU Jin(Pharmacy Department,Infection Hospital of Anhui Provincial Hospital,Hefei Infectious Disease Hospital,Hefei 230001,China;Six Disease Area of Infection Department,Infection Hospital of Anhui Provincial Hospital,Hefei Infectious Disease Hospital,Hefei 230001,China)

机构地区：[1]安徽省立医院感染病院合肥市传染病医院药剂科,安徽合肥230001 [2]安徽省立医院感染病院合肥市传染病医院感染科六病区,安徽合肥230001

出　　处：《实用药物与临床》2022年第9期798-802,共5页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨卡瑞利珠单抗所致反应性皮肤毛细血管内皮细胞增殖(RCCEP)与肿瘤反应的相关性。方法回顾性分析我院70例晚期肝细胞肝癌患者使用卡瑞利珠单抗后RCCEP的发生率、临床病理特征和预后价值。结果在随访18个月的时间内,70例接受卡瑞利珠单抗治疗的患者中有52例(74.3%)出现RCCEP。RCCEP发生在皮肤表面,主要发生在头、脸和躯干。根据形态学特征,RCCEP可分为“红痣样”、“珍珠样”、“桑椹样”、“斑片状”和“肿瘤样”5种类型。RCCEP病理显示真皮毛细血管内皮增生和毛细血管增生。RCCEP的发生率与较高的客观缓解率(ORR)之间存在显著相关性(36.5%vs.11.1%,P=0.042)。结论RCCEP发生在皮肤表面,是皮肤毛细血管内皮细胞的一种免疫反应。RCCEP的发生与晚期肝细胞癌患者卡瑞利珠单抗的肿瘤反应呈正相关。Objective To investigate the correlation between reactive cutaneous capillary endothelial proliferation(RCCEP)induced by carrelizumab and tumor response.Methods The occurrence,clinicopathological characteristics and prognostic value of RCCEP in 70 patients with advanced hepatocellular carcinoma(HCC)after using carrelizumab in our hospital were retrospectively analyzed.Results During the 18-month follow-up period,52 cases(74.3%)of 70 patients treated with camerizumab developed RCCEP.RCCEP occurred on the surface of the skin,mainly on the head,face and trunk.According to the morphological characteristics,RCCEP could be divided into five types:“pink mole-like”,“pearl-like”,“mulberry-like”,“patchy-like”and“tumor-like”.RCCEP pathology showed dermal capillary endothelial hyperplasia and capillary hyperplasia.A significant correlation was observed between the incidence of RCCEP and the higher objective response rate(ORR)(36.5%vs.11.1%,P=0.042).Conclusion RCCEP occurs on the skin surface and is an immune response of skin capillary endothelial cells.The occurrence of RCCEP is positively correlated with the tumor response of camerizumab in patients with advanced HCC.

关 键 词：卡瑞利珠单抗 反应性皮肤毛细血管内皮细胞增殖 肝细胞肝癌 免疫相关不良反应 

分 类 号：R735.7[医药卫生—肿瘤]