circEPSTI1与恶性肿瘤关系的研究进展  

Progress in relationship between circEPSTI1 and malignant tumors

作　　者：高露 王会莹 董学君[1] GAO Lu;WANG Hui-ying;DONG Xue-jun(Zhejiang University Shaoxing Hospital,Shaoxing 312000,China;Shaoxing University School of Medicine,Shaoxing 312000,China)

机构地区：[1]浙江大学绍兴医院,浙江绍兴312000 [2]绍兴文理学院医学院,浙江绍兴312000

出　　处：《中国病理生理杂志》2022年第9期1716-1721,共6页Chinese Journal of Pathophysiology

基　　金：绍兴市公益性技术应用研究计划项目(No.2020A13007);浙江省医药卫生科研计划项目(No.2022KY1284)。

摘　　要：环状RNA(circular RNA,circ RNA)是一类具有共价闭合环状结构的内源性非编码RNA,不具有5’帽状结构和3’腺苷酸尾结构。由于其闭合环状结构对核酸外切酶具有较高的耐受性,circ RNA不易被降解,因此,可稳定存在于真核生物细胞的细胞质中。1976年,circ RNA首次被Sanger等[1]发现,最初认为是RNA错误剪接所产生的无功能产物。随着生物信息学和高通量测序技术等的发展,大量研究报道circ RNA在肿瘤中具有海绵化微小RNA(micro RNA)。Circular RNAs(circRNAs)are formed by reverse shearing of progenitor messenger RNA. The3’and 5’ clipping domains are long circular non-coding RNAs linked by covalent bonds. circRNAs are not easily degraded by the exonuclease. Motifs of circRNAs have demonstrated sequence conservation and tissue-specific properties. Studies in recent years have shown that the abnormal expression of circRNAs can affect the occurrence and development of various malignant tumors. circEPSTI1 is a member of circRNA,which is identified as a up-regulated circRNA in triple-negative breast cancer by microarray analysis. circEPSTI1 is differentially expressed in ovarian cancer,osteosarcoma,non-smallcell lung cancer,oral squamous cell carcinoma and cervical cancer compared with normal tissues,and is closely related to tumor occurrence and development. It can be a potential target for tumor treatment and prognostic biomarkers. This paper reviews the molecular mechanism of circEPSTI1 in tumors and its related roles in tumor initiation and progression.

关 键 词：环状RNA circEPSTI1 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤] R363[医药卫生—临床医学]