A-FABP、NMP22联合Pyk2检测对肌层浸润性膀胱癌的诊断价值分析  

Value of A-FABP and NMP22 Combined with Pyk2 Detection in Diagnosis of Patients with Muscle Invasive Bladder Cancer

作　　者：王强[1] 罗涵云 徐述雄[2] 王晓东[2] 王元林[2] WANG Qiang;LUO Han-yun;XU Shu-xiong;WANG Xiao-dong;WANG Yuan-lin(Guizhou Medical University,Guiyang 550002,China;Department of Urinary Surgery,the People's Hospital of Guizhou City,Guiyang 550002,China)

机构地区：[1]贵州医科大学,贵阳550002 [2]贵州省人民医院泌尿外科,贵阳550002

出　　处：《解放军医药杂志》2022年第7期35-38,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：贵阳市科技计划项目(20161001)。

摘　　要：目的研究脂肪型脂肪酸结合蛋白(A-FABP)、尿核基质蛋白22(NMP22)联合酪氨酸蛋白激酶2(Pyk2)检测对肌层浸润性膀胱癌的诊断价值。方法选取本院2017年2月—2020年5月收治的124例肌层浸润性膀胱癌,取癌组织标本和癌旁正常组织,比较不同组织Pyk2、A-FABP、NMP22表达情况及与临床病理特征的关系;应用受试者工作特征(ROC)曲线分析3项指标对肌层浸润性膀胱癌的诊断价值。结果癌组织Pyk2、A-FABP、NMP22阳性表达率均高于癌旁正常组织(P<0.01)。Pyk2、A-FABP、NMP22阳性率病理分期Ⅲ期患者明显高于Ⅰ期、Ⅱ期患者,低分化患者明显高于中分化及高分化患者(P<0.01)。ROC曲线分析显示,Pyk2、A-FABP、NMP22三者联合诊断肌层浸润性膀胱癌的敏感度、特异度分别为0.855、0.912,显著高于各指标单一检测。结论A-FABP、NMP22联合Pyk2检测可提高肌层浸润性膀胱癌的诊断率。Objective To study the value of adipose fatty acid-binding protein(A-FABP),urinary nuclear matrix protein 22(NMP22)combined with protein tyrosine kinase 2(Pyk2)in diagnosis of patients with muscle invasive bladder cancer(MIBC).Methods A total of 124 patients with MIBC admitted between February 2017 and May 2020 were selected,and cancer tissues and adjacent normal tissues were taken out.Expressions of Pyk2,A-FABP and NMP22 in different tissues and their correlations with clinicopathological features were compared,and values of the three indexes in diagnosis of patients with MIBC were analyzed by receiver operating characteristic(ROC)curve.Results The positive expression rates of Pyk2,A-FABP and NMP22 in cancer tissues were higher than those in adjacent normal tissues(P<0.01).Numbers of positive rates of Pyk2,A-FABP and NMP22 in patients with pathological stage Ⅲ were significantly higher than those in patients with stage Ⅰ and Ⅱ,and the numbers in patients with low differentiation were significantly higher than those in patients with medium and high differentiation(P<0.01).ROC curve analysis showed that the sensitivity and specificity of combined detection of Pyk2,A-FABP and NMP22 in diagnosis of patients with MIBC were 0.855 and 0.912 respectively,which were significantly higher than those by single detection.Conclusion A-FABP,NMP22 combined with Pyk2 may improve the diagnostic rate of patients with MIBC.

关 键 词：膀胱肿瘤 脂肪酸结合蛋白质类 尿核基质蛋白22 蛋白酪氨酸激酶类 

分 类 号：R737.14[医药卫生—肿瘤]