调强放射治疗对食管癌患者外周血Treg细胞、血清肿瘤标志物及应激激素水平的影响  

Effects of Intensity Modulated Radiation Therapy on Peripheral Blood Treg Cells, Serum Tumor Markers and Stress Hormone Levels in Patients with Esophageal Cancer

作　　者：曹姝 刘义 晏军[1] 陈晓梅[1] 兰敏 CAO Shu;LIU Yi;YAN Jun;CHEN Xiao-mei;LAN Min(Department of Oncology,Zigong First People's Hospital,Zigong,Sichuan,643000,China;School of Chemical Engineering,Sichuan University of Light Chemical Industry,Zigong,Sichuan,643000,China)

机构地区：[1]自贡市第一人民医院肿瘤科,四川自贡643000 [2]四川轻化工大学化学工程学院,四川自贡643000

出　　处：《现代生物医学进展》2022年第16期3177-3181,共5页Progress in Modern Biomedicine

基　　金：四川省医学科研课题计划项目(S18070);国家自然科学基金项目(81827056)。

摘　　要：目的:观察调强放射(IMRT)治疗对食管癌患者外周血调节性T细胞(Treg)细胞、血清肿瘤标志物及应激激素水平的影响。方法:选取2019年9月~2021年3月期间自贡市第一人民医院收治的食管癌患者80例,按照随机数字表法将患者分为对照组(普通适形放疗,40例)和研究组(IMRT治疗,40例)。对比两组临床总有效率、外周血Treg细胞比例、血清肿瘤标志物及应激激素水平,观察放疗期间出现的不良反应。结果:研究组的临床总有效率高于对照组(P<0.05)。两组放疗后癌胚抗原(CEA)、糖类抗原199(CA199)、细胞角蛋白19片段(CYFRA21-1)均下降,且研究组低于对照组(P<0.05)。两组放疗后生长激素(GH)、催乳素(PRL)均下降,且研究组低于对照组(P<0.05)。两组放疗后外周血Treg细胞占CD4~+T细胞的比例下降,且研究组较对照组低(P<0.05)。不良反应发生率两组组间对比,未见显著性差异(P>0.05)。结论:食管癌患者采用IMRT治疗,可有效降低外周血Treg细胞比例、血清肿瘤标志物及应激激素水平,疗效较好,具有一定的临床应用价值。Objective: To observe the effects of intensity modulated radiation therapy(IMRT) on peripheral blood regulatory T cells(Treg) cells, serum tumor markers and stress hormone levels in patients with esophageal cancer. Methods: 80 patients with esophageal cancer who were treated in Zigong First People’s Hospital from September 2019 to March 2021 were selected. According to the random number table method, the patients were divided into control group(general conformal radiotherapy, 40 cases) and study group(IMRT treatment, 40 cases). The total clinical effective rate, the proportion of peripheral blood Treg cells, serum tumor markers and stress hormone levels were compared between the two groups, and the adverse reactions during radiotherapy were observed. Results:The total clinical effective rate of the study group was higher than that of the control group(P<0.05). After radiotherapy, carcinoembryonic antigen(CEA), carbohydrate antigen 199(CA199) and cytokeratin 19 fragment(CYFRA21-1) decreased in the two groups, and the study group was lower than the control group(P<0.05). Growth hormone(GH) and prolactin(PRL) decreased after radiotherapy in the two groups, and the study group was lower than the control group(P<0.05). After radiotherapy, the proportion of peripheral blood Treg cells in CD4T cells decreased in the two groups, and the study group was lower than the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: IMRT treatment in patients with esophageal cancer can effectively reduce the proportion of peripheral blood Treg cells, serum tumor markers and stress hormone levels. It has good curative effect and has certain clinical application value.

关 键 词：调强放射治疗 食管癌 外周血Treg细胞 肿瘤标志物 应激激素 

分 类 号：R735.1[医药卫生—肿瘤]