DDIT3对肿瘤的影响及其相关药物研究进展  

Research progress on the effects of DDIT3 on tumor and related drugs

作　　者：黄国庆[1] 曹涤非[1] 薛佳莹[1] HUANG Guo-qing;CAO Di-fei;XUE Jia-ying(Department of Biotechnology,Institute of Advanced Technology,Heilongjiang Academy of Sciences,Harbin 150020,China)

机构地区：[1]黑龙江省科学院高技术研究院生物技术研究室,黑龙江哈尔滨150020

出　　处：《生物技术》2022年第4期521-527,共7页Biotechnology

基　　金：黑龙江省自然科学基金项目(LH2021H056);黑龙江省科学院青年创新基金杰青项目(CXJQ2019GJS01)。

摘　　要：DDIT3作为多种癌症治疗靶点日益受到重视,相应药物也被广泛研究开发。DDIT3作为调控细胞凋亡的关键因素很可能是多种疾病临床治疗的突破口,有望成为抗肿瘤药物研发的新靶点。该文综述了DNA损伤诱导转录因子DDIT3的表达对肿瘤发生发展的影响及其临床意义,分析了DDIT3在内质网应激下诱导细胞凋亡的作用机制,总结了在肿瘤微环境下DDIT3的调控途径及其对细胞稳态的影响,也对靶向DDIT3的肿瘤临床前及实验室阶段的药物进行了汇总并阐明其作用机制。As DDIT3 was received increasing attention as a therapeutic target for many cancers,it is also being widely studied and developed.As a key factor regulating apoptosis,DDIT3 is likely to be a breakthrough in the clinical treatment of various diseases,and is also expected to become a new target for anti-tumor drug development in the future.It reviewed the effect of DNA damage-induced transcription factor 3 on tumor development and its clinical significance.It analyzed the mechanism of DDIT3 induced apoptosis in endoplasmic reticulum stress,and summarized the regulatory pathway of DDIT3 and its effect on cell homeostasis in tumor microenvironment.It also summarized the vast majority of preclinical and laboratory drugs targeting DDIT3 and elucidated their mechanisms of action.

关 键 词：DDIT3 肿瘤微环境 内质网应激 

分 类 号：R730.4[医药卫生—肿瘤]