米诺环素联合莫西沙星治疗急性智齿冠周炎的临床疗效及对冠周袋内微生物的影响  

Clinical Efficacy of Minocycline Combined with Moxifloxacin in Patients with Acute Wisdom Tooth Pericoronitis and Its Effect on the Microorganisms in the Pericoronal Pocket

作　　者：黄斯佳 蔡毅超 陈江[2] HUANG Sijia;CAI Yichao;CHEN Jiang(Quanzhou Medical College,Quanzhou 362000,China;Affliated Stomatological Hospital of Fujian Medical University,Fuzhou 350004,Fujian,China)

机构地区：[1]泉州医学高等专科学校,福建泉州362000 [2]福建医科大学附属口腔医院,福建福州350004

出　　处：《中国药物滥用防治杂志》2022年第8期1102-1105,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨米诺环素联合莫西沙星治疗急性智齿冠周炎患者的临床疗效及对冠周袋内微生物的影响。方法:选择2019年1月—2021年10月我本院门诊收治的急性智齿冠周炎100例患者作为研究对象,根据随机1∶1信封抽签原则把患者分为研究组与对照组,各50例。对照组给予阿莫西林联合米诺环素治疗,研究组给予莫西沙星联合米诺环素治疗,比较两组治疗效果、唾液8-OHdG含量、炎症因子(IL-2、IL-4)、冠周袋牙龈液chao指数。结果:研究组总有效率为98.0%,高于对照组的84.0%(P<0.05);研究组8-OHdG含量低于对照组(P<0.05);研究组IL-2、IL-4水平低于对照组(P<0.05);研究组冠周袋牙龈液chao指数低于对照组(P<0.05)。结论:米诺环素联合莫西沙星可降低急性智齿冠周炎患者冠周袋内微生物丰度,能有效抑制唾液中8-OHdG释放,抑制血清IL-2、IL-4的表达,从而提高治疗效果。Objective:To investigate the clinical efficacy of minocycline combined with moxifloxacin in the treatment of patients with acute wisdom tooth pericoronitis and its effect on microorganisms in pericoron pocket.Methods:A total of 100 patients with acute wisdom tooth pericoronitis admitted to our hospital from January 2019 to October 2021 were selected as the research subjects.According to the random 1∶1 envelope drawing principle,the patients were divided into study group and control group,with 50 cases in each group.The control group was treated with amoxicillin combined with minocycline,and the study group was treated with moxifloxacin combined with minocycline.The therapeutic effect,salivary 8-OHdG content,inflammatory factors(IL-2,IL-4)and chao index of periodontal pocket gingival fluid were compared between the two groups.Results:The total effective rate of the study group was 98.0%,which was higher than 84.0%of the control group(P<0.05).The content of 8-OHdG in the study group was lower than that in the control group(P<0.05).The levels of IL-2 and IL-4 in the study group were lower than those in the control group(P<0.05).The chao index of gingival fluid in the study group was lower than that in the control group(P<0.05).Conclusion:Minocycline combined with moxifloxacin can reduce the microbial abundance in pericoronal pocket of patients with acute wisdom tooth pericoronitis,effectively inhibit the release of 8-OHdG in saliva,and inhibit the expression of IL-2 and IL-4 in serum,thereby improving the therapeutic effect.

关 键 词：米诺环素 莫西沙星 急性智齿冠周炎 冠周袋 微生物 

分 类 号：R782.31[医药卫生—口腔医学]