烷氧基三联吡啶钌配合物的合成、结构及其与DNA相互作用  

Synthesis,Structure,and Interaction with DNA of Alkoxy Tribipyridine Ruthenium Complexes

作　　者：郭辉[1] 汪涛 苏文卿 李丹[1] 陈兴星 吴杰颖[1] 张琼[1,3] 田玉鹏[1,3] GUO Hui;WANG Tao;SU Wen-Qing;LI Dan;CHEN Xing-Xing;WU Jie-Ying;ZHANG Qiong;TIAN Yu-Peng(Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province,Department of Chemistry,Anhui University,Hefei 230601,China;School of Life Science,Anhui University,Hefei 230601,China;State Key Laboratory of Coordination Chemistry,Nanjing University,Nanjing 210023,China)

机构地区：[1]安徽大学化学系,功能无机材料化学安徽省重点实验室,合肥230601 [2]安徽大学生命科学学院,合肥230601 [3]南京大学配位化学国家重点实验室,南京210023

出　　处：《无机化学学报》2022年第10期2019-2027,共9页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.21871003);安徽省自然科学基金(No.2008085QB52)资助。

摘　　要：制备了2种含长基链的烷氧基三联吡啶和2,2'⁃联吡啶配位的钌配合物(Ru⁃Cl、Ru⁃NCMe),通过质谱、核磁和单晶X射线衍射分析等进行了表征。从它们的晶体结构可以发现Ru⁃Cl配合物中第6个配位点为Cl-离子,在Ru⁃NCMe配合物中的第6个配位点为乙腈分子中的N原子。通过紫外可见吸收光谱和荧光光谱研究了这2种配合物与多种氨基酸和DNA的作用,发现这种长烷基链和刚性配位平面的配合物与DNA具有明显的特异性识别效应,进一步研究发现它们与DNA以插入方式和静电作用结合,实验与理论模拟结果一致。Two ruthenium complexes(Ru⁃Cl,Ru⁃NCMe)containing long alkoxy tribipyridine and 2,2'⁃bipyridine were synthesized and characterized by mass spectrometry,NMR,single crystal X⁃ray diffraction analysis,etc.Based on their crystal structural information,it can be found that the sixth coordination position in complex Ru⁃Cl is Clion,and the sixth coordination position in complex Ru⁃NCME is N atom in acetonitrile molecule.The interaction of the two complexes with various amino acids and DNA was studied by UV⁃Vis absorption and fluorescence spectros⁃copy.It was found that the complexes with long alkyl chains and rigid coordination planes had an obvious specific recognition effect on DNA.Further study found that they could bind DNA in the way of insertion and electrostatic.Both results of the experiments and the theoretical calculation were consistent.CCDC:1063055,Ru⁃Cl;1577329,Ru⁃NCME.

关 键 词：钌配合物 三联吡啶 晶体结构 DNA响应 

分 类 号：O614.821[理学—无机化学]