颗粒酶介导肿瘤细胞凋亡的研究进展  

Progress of granzyme-induced apoptosis in tumor cells

作　　者：宋东峰 邬一鸣 李燕京[1] Song Dongfeng;Wu Yiming;Li Yanjing(Department of Medical Oncology,Harbin Medical University Cancer Hospital,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院肿瘤内科,哈尔滨150081

出　　处：《肿瘤研究与临床》2022年第8期634-637,共4页Cancer Research and Clinic

基　　金：国家自然科学基金(81602662);吴阶平基金(320.6750.2020-05-17);哈尔滨医科大学附属肿瘤医院科学研究基金(BJQN2018-02、JJZD2021-08、JCQN2021-03)。

摘　　要：颗粒酶存在于细胞毒性颗粒中, 是高度同源的丝氨酸蛋白酶家族, 由自然杀伤细胞、细胞毒性淋巴细胞合成并释放, 在穿孔素的参与下介导多种程序性死亡方式, 是免疫细胞发挥抗肿瘤作用的重要介质。文章对颗粒酶介导肿瘤细胞死亡、颗粒酶与各种细胞凋亡方式的关系进行综述, 以期为肿瘤治疗提供新的理论依据和治疗策略。Granzyme exists in the cytotoxic granules and belongs to a highly homologous serine protease family.Granzyme is synthesized and released from natural killer cells and cytotoxic lymphocytes.It induces multiple programmed death with the participation of perforin and is an important medium for immune cells to exert anti-tumor effects.This article reviews the granzyme-mediated tumor cell death and the relationship between granzyme and kinds of ways of cell apoptosis,in order to provide new theoretical basis and therapeutic strategies for tumor therapy.

关 键 词：肿瘤 颗粒酶 细胞凋亡 细胞焦亡 

分 类 号：R730.2[医药卫生—肿瘤]