鼠李糖乳杆菌对炎症性肠病的影响机制研究进展  

Advances in the Mechanism of Lactobacillus rhamnosus GG Improving Inflammatory Bowel Disease

作　　者：岑秋宇 庞日朝 崔艳如 魏娟芳 张安仁 CEN Qiuyu;PANG Rizhao;CUI Yanru;WEI Juanfang;ZHANG Anren(School of Health Preservation and Rehabilitation,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Department of Rehabilitation Medicine,General Hospital of the Western Theater of the Chinese People's Liberation Army,Chengdu 610083,China;Department of Rehabilitation Medicine,Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine,Shanghai 200434,China)

机构地区：[1]成都中医药大学养生康复学院,四川省成都市610075 [2]中国人民解放军西部战区总医院康复医学科,四川省成都市610083 [3]同济大学附属上海市第四人民医院康复医学科,上海市200434

出　　处：《中国全科医学》2022年第36期4595-4600,共6页Chinese General Practice

基　　金：国家自然科学基金面上项目(81973927)。

摘　　要：炎症性肠病(IBD)在我国的发病率逐年上升。随着微生物-宿主相互作用的发现,人们意识到肠道微生物群对IBD的发生、发展至关重要。由此提示,从调节肠道微生物角度出发,可能是治疗IBD的新策略。鼠李糖乳杆菌(LGG)是目前应用广泛的益生菌菌株之一,其可通过调节肠道微生物组成、维持肠上皮屏障完整性、调节肠道免疫反应、抑制氧化应激、改善焦虑抑郁状态等途径达到缓解IBD的目的。因此,本文就LGG对IBD的作用机制做一综述,以期为其临床应用提供理论支持。China is seeing an increasing prevalence of inflammatory bowel disease(IBD).During the process of exploring treatments for IBD,gut microbiota has been found to be crucial to the development of IBD along with the discovery of microbial-host interactions,suggesting that modulating gut microbiota may be a new strategy for the treatment of IBD.Recent studies have shown that Lactobacillus rhamnosus GG(LGG),one most widely used probiotic strain,can achieve IBD alleviation by regulating intestinal microbial composition,maintaining intestinal epithelial barrier integrity,modulating intestinal immune response,inhibiting oxidative stress,and improving anxiety-depression status.Therefore,this paper presents a review of the mechanism of action of LGG in improving IBD,providing theoretical support for its clinical application.

关 键 词：肠疾病 炎症性肠病 鼠李糖乳杆菌 胃肠道微生物组 肠-脑轴 

分 类 号：R574[医药卫生—消化系统]