牙周炎与血管内皮细胞功能障碍相关关系的研究进展  

Research progress in association between endothelial dysfunction and periodontitis

作　　者：杨树荣 任秀云[1] Yang Shurong;Ren Xiuyun(Department of Periodontology,Shanxi Medical University School and Hospital of Stomatology&Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials,Taiyuan 030001,China)

机构地区：[1]山西医科大学口腔医学院·口腔医院牙周科,口腔疾病防治与新材料山西省重点实验室,太原030001

出　　处：《中华口腔医学杂志》2022年第9期973-977,共5页Chinese Journal of Stomatology

基　　金：国家自然科学基金(81271144)。

摘　　要：血管内皮是抵御心血管疾病的基础防线,炎症因子、氧化应激及生物因素等多种因素可引起内皮细胞功能障碍,参与心血管疾病的发生发展。牙周炎是心血管疾病的独立危险因素,近年研究发现,牙周炎与血管内皮功能障碍相关,牙周治疗可以改善血管内皮功能。本文列举了近年牙周炎与内皮功能障碍相关性的证据,分析牙周炎加重血管内皮细胞功能障碍的可能机制,强调牙周干预治疗对改善内皮功能的重要性,为牙周炎与心血管疾病关系的深入研究及防治策略提供新思路。Vascular endothelium formulates the basic defense against cardiovascular diseases.Multiple factors such as inflammatory factors,oxidative stress and biological factors can cause endothelial dysfunction and be involved in the formation and development of cardiovascular diseases.In studies of recent years,accumulated evidences showed that periodontitis was an independent risk factor for cardiovascular events,and was related to vascular endothelial dysfunction.Periodontal therapy could improve the vascular endothelial function.In this paper,the epidemiological evidences of associations between periodontitis and vascular endothelial dysfunction in recent years were listed,and the possible mechanisms of periodontitis aggravating endothelial dysfunction were analyzed.The importance of periodontal intervention in improving endothelial function was emphasized.This will provide new ideas for further study about the relationship between periodontitis and cardiovascular diseases and for the prevention and treatment strategies.

关 键 词：牙周炎 干预性研究 血管内皮功能障碍 心血管疾病 牙周干预治疗 

分 类 号：R781.42[医药卫生—口腔医学] R54[医药卫生—临床医学]