血浆热休克蛋白90α水平与脑小血管病患者脑白质高信号的相关性  

The correlation between plasma heat shock proteins 90αlevels and white matter hyperintensity in patients with cerebral small vessel disease

作　　者：蔚文锴 王运超[1] 李亚鹏[1] 高远[1] 宗策 许予明[1] 李玉生[1] Yu Wenkai;Wang Yunchao;Li Yapeng;Gao Yuan;Zong Ce;Xu Yuming;Li Yusheng(Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院神经内科,郑州450000

出　　处：《中华医学杂志》2022年第33期2602-2606,共5页National Medical Journal of China

基　　金：国家自然科学基金面上项目(82171300)。

摘　　要：目的探究血浆热休克蛋白90α(Hsp90α)水平与脑小血管病患者脑白质高信号之间的关系。方法以2021年3—8月期间郑州大学第一附属医院神经内科收治的并且磁共振检查诊断为脑小血管病脑白质高信号的患者为病例组,匹配同期于该院体检科就诊的,磁共振检查显示无脑白质高信号且没有神经系统疾病史的体检者为对照组,检测其血浆Hsp90α水平。采用Mann-WhitneyU检验对比对照组与病例组中血浆Hsp90α水平是否存在差异,采用多因素logistic回归模型分析脑小血管病患者中脑白质高信号的相关因素。结果在183例研究对象中,对照组73例,男28例,女45例,年龄(54±10)岁。病例组110例,男71例,女39例,年龄(64±10)岁。病例组血浆Hsp90α水平明显高于对照组[M(Q_(1),Q_(3))][53.33(35.33,70.09)ng/ml比35.02(18.51,54.95)ng/ml,P<0.001]。经过多因素logistic回归模型校正混杂因素后,血浆Hsp90α>58.34 ng/ml与脑小血管病脑白质高信号相关(OR=5.931,95%CI:1.955~17.995,P=0.002)。结论较高的血浆Hsp90α水平与脑小血管病脑白质高信号相关。Objective To investigate the relationship between plasma heat shock proteins 90α(Hsp90α)levels and the white matter hyperintensity(WMH)in patients with cerebral small vessel disease(SVD).Methods Patients admitted to the Department of Neurology,the First Affiliated Hospital of Zhengzhou University from March to August 2021 and diagnosed with WMH by magnetic resonance examination(MRI)were selected as the case group,matched with physical examination patients who visited the Department of Medical Examination during the same period and showed no WMH on MRI and no history of neurological diseases as the control group,and the level of plasma Hsp90αwas quantitatively detected by enzyme-linked immunosorbent assay.Mann-Whitney U test was used to compare whether there was a difference in plasma Hsp90αlevels between the control group and the case group.Multivariate logistic regression analysis was used to explore the related factors of WMH in patients with SVD.Results Of the 183 subjects,the control group(n=73)consisted of 28 males and 45 females,aged(54±10)years,while the case group(n=110)consisted of 71 males and 39 females,aged(64±10)years old.Plasma Hsp90αlevel was higher in the case group than that of the control group[53.33(35.33,70.09)ng/ml vs 35.02(18.51,54.95)ng/ml,P<0.001].After adjusting for confounding factors by multivariate analysis,the results showed that plasma Hsp90αlevels greater than 58.34 ng/ml was associated with WMH(P=0.002,OR=5.931,95%CI:1.955-17.995).Conclusion Higher level of plasma Hsp90αis associated with WMH in patients with SVD.

关 键 词：脑小血管病 白质高信号 热休克蛋白 酶联免疫吸附试验 病例对照研究 

分 类 号：R743[医药卫生—神经病学与精神病学]