乌司他丁对肺癌合并感染所致急性循环衰竭患者微循环指标、炎症因子水平及认知功能的影响  

Effect of ulinastatin on microcirculation indexes,inflammatory factors and cognition function in patients with acute circulatory failure caused by lung cancer co-infection

作　　者：杨亚娟 陈建 马西凡 YANG Yajuan;CHEN Jian;MAXifan(EICU,Xuchang Central Hospital Affiliated to He’nan University of Science and Technology,Xuchang 461000,He’nan,China;SICU,Xuchang Central Hospital Affiliated to He’nan University of Science and Technology,Xuchang 461000,He’nan,China;Department of Emergency,Xuchang Central Hospital Affiliated to He’nan University of Science and Technology,Xuchang 461000,He’nan,China)

机构地区：[1]河南科技大学附属许昌市中心医院EICU,河南许昌461000 [2]河南科技大学附属许昌市中心医院SICU,河南许昌461000 [3]河南科技大学附属许昌市中心医院急诊科,河南许昌461000

出　　处：《癌症进展》2022年第16期1674-1677,共4页Oncology Progress

摘　　要：目的探讨乌司他丁对肺癌合并感染所致急性循环衰竭患者微循环指标、炎症因子水平及认知功能的影响。方法根据治疗方式的不同将65例肺癌合并感染所致急性循环衰竭患者分为对照组(n=35)和乌司他丁组(n=30),对照组患者接受常规治疗,乌司他丁组患者在对照组的基础上接受乌司他丁治疗。比较两组患者的微循环指标[微血管流动指数(MFI)、总血管密度(TVD)、灌注血管密度(PVD)、灌注血管比例(PPV)]、炎症因子指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]及认知功能[简易精神状态量表(MMSE)]。结果治疗7天后,两组患者的TVD、PVD和PPV均高于本组治疗前,乌司他丁组患者的MFI高于本组治疗前,乌司他丁组患者的MFI、TVD、PVD和PPV均高于对照组,差异均有统计学意义(P﹤0.05)。治疗7天后,两组患者的TNF-α、IL-6和CRP水平均低于本组治疗前,乌司他丁组患者的TNF-α、IL-6和CRP水平均低于对照组,差异均有统计学意义(P﹤0.05)。治疗7天后,两组患者MMSE量表各维度评分和总分均高于本组治疗前,乌司他丁组患者MMSE量表各维度评分和总分均高于对照组,差异均有统计学意义(P﹤0.05)。结论乌司他丁对肺癌合并感染所致急性循环衰竭患者的治疗效果较好,可改善患者的微循环指标、炎症因子水平和认知功能,具有较好的临床应用价值。Objective To explore the effect of ulinastatin on microcirculation indexes,inflammatory factors and cognition function in patients with acute circulatory failure caused by lung cancer co-infection.Method A total of 65 patients with acute circulatory failure caused by lung cancer co-infection were divided into control group(n=35,received conventional treatment)and ulinastatin group(n=30,received ulinastatin on the basis of conventional treatment).The microcirculation indexes[microvascular flow index(MFI),total vessel density(TVD),perfused vessel density(PVD),proportion of perfused vessel(PPV)],inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)]and cognitive function[mini-mental state examination(MMSE)]of the two groups were compared.Result After 7 days of treatment,the levels of TVD,PVD and PPV in both groups and MFI in the ulinastatin group were higher than those before treatment,with higher levels of MFI,TVD,PVD and PPV in the ulinastatin group than those in the control group(P<0.05).After 7 days of treatment,the levels of TNF-α,IL-6 and CRP in the two groups were lower than those before treatment,with lower levels in the ulinastatin group than those in the control group(P<0.05).After 7 days of treatment,the scores of each dimension and total score of the MMSE in the two groups were higher than those before treatment,with higher scores in the ulinastatin group than those in the control group(P<0.05).Conclusion Ulinastatin has a good therapeutic effect on patients with acute circulatory failure caused by lung cancer co-infection,which can improve the microcirculation indexes,inflammatory factors and cognitive function with significant clinical application value.

关 键 词：乌司他丁 肺癌 感染 循环衰竭 

分 类 号：R734.2[医药卫生—肿瘤]