某儿童成长配方奶粉对微量营养素不足饲料喂养大鼠生长发育、骨量及钙吸收的影响  

Effects of a growth formula milk powder for children on growth,bone mass,and calcium absorption of rats fed micronutrient deficient diet

作　　者：黄斯妤 陈偲 何彤彤 叶兴旺 房洪涛 刘正冬 闫志远 朱惠莲[1] HUANG Si-yu;CHEN Si;HE Tong-tong;YE Xing-wang;FANG Hong-tao;LIU Zheng-dong;YAN Zhi-yuan;ZHU Hui-lian(School of Public Health,Sun Yat-sen University,Guangzhou 510080,China;Inner Mongolia Mengniu Dairy(Group)Co.Ltd.;Yashili International Group Ltd)

机构地区：[1]中山大学公共卫生学院,广东广州510080 [2]内蒙古蒙牛乳业(集团)股份有限公司 [3]雅士利国际集团有限公司

出　　处：《华南预防医学》2022年第7期792-796,共5页South China Journal of Preventive Medicine

摘　　要：目的 探讨采用儿童成长配方奶粉(以下简称配方奶粉)进行营养加强或营养补充后,对大鼠生长发育及骨密度等指标的影响。方法 断乳SD大鼠雌雄各半62只随机分成3组,分别饲以微量营养素不足饲料、营养素加强饲料、营养素补充饲料,监测大鼠身长和体重,8周后进行钙吸收实验。12周后测定全身、脊柱、四肢骨密度(BMD)和骨矿量(BMC)。结果 与营养素不足组相比,营养素加强组及营养素补充组雌性大鼠体重增长加快(均P<0.05),全身、脊柱与四肢BMD增加(均P<0.05),全身及四肢BMC增加(均P<0.05),营养素补充组雌性大鼠身长增长加快(P<0.05);与营养素不足组相比,营养素补充组雄性体重及身长增长加快(均P<0.05),营养素加强组及营养素补充组雄性大鼠全身、脊柱及四肢BMD增加(均P<0.05),全身及四肢BMC增加(均P<0.05),营养素补充组雄性大鼠脊柱BMC增加(P<0.05)。与营养素不足组相比,营养素加强组及营养素补充组雌雄大鼠钙吸收率上升(均P<0.05)。与营养素加强组相比,营养素补充组雄性大鼠体重、身长增长加快,全身BMC及四肢BMD和BMC增加(均P<0.05)。结论 配方奶粉强化AIN-93G饲料或在微量营养素不足饲料中添加配方奶粉对营养素不良饲料喂养的大鼠其身长、体重、BMD、BMC及钙吸收率均有所改善。且在雄性大鼠中,在微量营养素不足饲料中添加配方奶粉可实现对强化饲料在体重增长、BMD、BMC等方面的追赶。Objective To investigate the effects of nutrition enhancement or supplement with a growth formula milk powder for children(hereinafter referred to as formula)on growth and bone density of rats.Methods Sixty two weaned SD rats,half male and half female,were randomly assigned to three groups,which were fed with malnutrition diet,nutrition-enhanced diet,and nutrition-supplemented diet,respectively.The body length and weight of the rats were monitored.After 8 weeks of feeding,the calcium absorption test was carried out.After 12 weeks of feeding,bone mineral density(BMD)and bone mineral content(BMC)of the whole-body,spine bone,and limb bones were measured.Results Compared with the malnutrition group,the final body weight,BMD of whole body,spine,and limbs,BMC of whole body and limbs were significantly increased in female rats of the nutrition-enhanced group and the nutrition-supplemented group(all P<0.05),the final body length were increased in female rats of the nutrition-supplemented group(P<0.05).Compared with the malnutrition group,the final body weight and body length were increased in male rats of the nutrition-supplemented group(all P<0.05),while BMD of whole body,spine and limbs,BMC of whole body and limbs were increased in male rats of the nutrition-enhanced group and the nutrition-supplemented group(all P<0.05).Compared with the malnutrition group,BMC of spine was increased in male rats of the nutrition-supplemented group(P<0.05).Compared with the malnutrition group,the calcium absorption rate was increased in both male and female rats of the nutrition-enhanced group and the nutrition-supplemented group(all P<0.05).Compared with the nutrition-enhanced group,the body weight and body length of male rats in the nutrition-supplemented group increased faster,and the BMC of whole body,BMD and BMC of limbs increased(all P<0.05).Conclusion The body length,body weight,BMD,BMC,and calcium absorption rate of rats fed with micronutrient deficient diet were improved by supplementation of formula with AIN-93G or malnutriti

关 键 词：营养素不足 骨量 钙吸收 生长发育 

分 类 号：R151.3[医药卫生—营养与食品卫生学]