Function toggle of tumor microenvironment responsive nanoagent for highly efficient free radical stress enhanced chemodynamic therapy  

作　　者：Xueting Yang Shuaitian Guo Li Wang Shanyue Guan Shuyun Zhou Jun Lu 

机构地区：[1]State Key Laboratory of Chemical Resource Engineering,Beijing University of Chemical Technology,Beijing 100029,China [2]Key Laboratory of Photochemical Conversion and Optoelectronic Materials,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China [3]University of Chinese Academy of Sciences,Beijing 100190,China [4]Beijing Advanced Innovation Center for Soft Mater Science and Engineering,Beijing University of Chemical Technology,Beijing 100029,China

出　　处：《Nano Research》2022年第9期8228-8236,共9页纳米研究（英文版）

基　　金：the financial support from the National Natural Science Foundation of China(No.21571013,52073023,and 21805293);the National Basic Research Program(No.2014CB932101);the Program for Chang Jiang Scholars,Innovative Research Team in University(No.IRT1205);the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2019027);the Director Foundation of the Technical Institute of Physics and Chemistry,Chinese Academy of Sciences.

摘　　要：In contrast to reactive oxygen species(ROS),the generation of oxygen-irrelevant free radicals is oxygen-and H2O2-independent in cell,which can offer novel opportunities to maximum the chemodynamic therapy(CDT)efficacy.Herein,an H2O2-independent“functional reversion”strategy based on tumor microenvironment(TME)-toggled C-free radical generation for CDT is developed by confining astaxanthin(ATX)on the NiFe-layered double hydroxide(LDH)nanosheets(denoted as ATX/LDH).The unique ATX/LDH can demonstrate outstanding TME-responsive C-free radical generation performance by proton coupled electron transfer(PCET),owing to the specific ATX activation by unsaturated Fe sites on the LDH nanosheets formed under TME.Significantly,the Brönsted base sites of LDH hydroxide layers can promote the generation of neutral ATX C-free radicals by capturing the protons generated in the ATX activation process.Conversely,ATX/LDH maintain antioxidant performance to prevent normal tissue cancerization due to the synergy of LDH nanosheets and antioxidative ATX.In addition,C-free radical can compromise the antioxidant defense in cells to the maximum extent,compared with ROS.The free radicals burst under TME can significantly elevate free radical stress and induce cancer cell apoptosis.This strategy can realize TME-toggled C free radical generation and perform free radical stress enhanced CDT.

关 键 词：ultrathin layered double hydroxide nanosheets ASTAXANTHIN free radical chemodynamic therapy 

分 类 号：R730.5[医药卫生—肿瘤]