Synergistic anti-tumor therapy by a homotypic cell membranecloaked biomimetic nanocarrier with exceptionally potent activity against hepatic carcinoma  

作　　者：Shini Feng Pinyue Ni Yan Gong Bijiang Geng Hui Li Chenlin Miao Ruyu Fan Levon Galstyan Dengyu Pan Fuxue Chen Huafei Li 

机构地区：[1]School of Lifesciences,Shanghai University,Shanghai 200444,China [2]School of Environmental and Chemical Engineering,Shanghai University,Shanghai 200444,China [3]SLAVMED Medical Center,Manandyan st.,9 bld.,Yerevan 0037,Republic of Armenia

出　　处：《Nano Research》2022年第9期8255-8269,共15页纳米研究（英文版）

基　　金：“One Belt One Road”International Cooperation Project of Shanghai Municipal Committee of Science and Technology(No.19410740900);the National Natural Science Foundation of China(No.52002239);the International Science and Technology Cooperation Programme of Ministry of Science and Technology of China(No.2019YFE0116800);Natural Science Foundation of Shanghai(No.21ZR1422800).

摘　　要：Hepatic carcinoma(HC)is the sixth most frequently occurring malignancies and the third leading cause of cancer death worldwide.Sepantronium bromide(YM155)is a small molecule inhibitor of survivin,which has broad-spectrum anticancer therapeutic effects in various xenograft models.However,several-day continuous infusion is required to achieve greater antitumor efficacy because of rapid elimination from the blood circulation.Herein,a SMMC-7721 cancerous cyto-membrane-cloaked drug delivery system(DDS)(named as iM7721@GQD-YM),was developed for co-encapsulation of YM155 and graphene quantum dots(GQDs).Cytomembrane coating endowed iM7721@GQD-YM with effective targeting for homologous HC cells,excellent biocompatibility and favorable immunocompatibility for in vivo application.Surface decoration of iRGD peptide further enhanced its tumor targeting activity by iRGD-integrin recognition.In addition,under the irradiation of near-infrared ray(NIR),GQDs can directly kill tumors through photothermal effect and cause cell membrane rupture,accurately releasing YM155 at tumor sites.The physicochemical properties,in vivo and ex vivo anti-tumor efficacy,and mechanisms of iM7721@GQD-YM nanoparticles(NPs)were systematically investigated in this work.The experimental results clearly indicate that the versatile biomimetic DDS holds great potential for the treatment of HC,which merits further investigation in both pre-clinical and clinical studies.

关 键 词：hepatic carcinoma sepantronium bromide(YM155) cancer cell membrane biomimetic drug delivery system graphene quantum dots photothermal effect 

分 类 号：R735.7[医药卫生—肿瘤]