Mild hyperthermia synergized chemotherapy by Bi_(2)Se_(3)/MoSe_(2)nanosaucers for cancer treatment with negligible thermal resistance  

作　　者：Fei Gao Tingbin Zhang Yuqing Miao Huijun Ma Hui Guo Ruyi Jin Zhi Li Haifang Wang Haiming Fan Lingyun Zhao 

机构地区：[1]Institute of Integrative Medicine,Shaanxi University of Chinese Medicine,Xi'an 712046,China [2]Key Laboratory of Advanced Materials,Ministry of Education of China,School of Materials Science&Engineering,Tsinghua University,Beijing 100084,China [3]College of Pharmacy,Shaanxi University of Chinese Medicine,Xi'an 712046,China [4]Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education,College of Chemistry and Materials Science,Northwest University,Xi’an 710069,China [5]Shaanxi Key Laboratory of Integrative Traditional Chinese and Western Medicine for Prevention and Treatment of Cardiovascular Diseases,Institute of Integrative Medicine,Shaanxi University of Chinese Medicine,Xi'an 712046,China

出　　处：《Nano Research》2022年第9期8270-8280,共11页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China for the financial support(Nos.51971116,81771981,and 32001005);Shaanxi Provincial Science and Technology Department for financial support(No.2021JM-476);Shaanxi Provincial Administration of Traditional Chinese Medicine for financial support(No.20211-ZZ-JC007).

摘　　要：Harsh photothermal temperatures(>50℃)caused heating damage to the normal tissues and induced thermal resistance in cancer cells,which significantly limited the safety and efficacy of photothermal therapy(PTT)in cancer treatment.Mild hyperthermia(<42℃)combined with chemotherapy might solve this issue.Herein,a novel transition metal dichalcogenides nanostructure,namely,Bi_(2)Se_(3)/MoSe_(2)nanosaucers(BMNSs),was designed to produce mild photo-hyperthermia(mPTT)and combined with chemotherapy to improve the overall antitumor efficacy.The BMNSs were constituted by Bi_(2)Se_(3)hexagonal nanoplates and enclosed with MoSe_(2)nanosheets evenly.While the MoSe_(2)moiety endowed the nanoplatform with excellent photothermal efficacy,the Bi_(2)Se_(3)substrates provided large specific surface area to anchor more doxorubicin(DOX)molecules as chemotherapeutic agent.Under the stimuli of mPTT/tumor acidic microenvironment,the tumor-specific drug release and the enhanced chemotherapy could be realized,showing impressive therapeutic outcomes against 4T1 cells.The synergetic therapeutic mechanism might be attributed to the mPTT induced cell membrane permeability,and interestingly,the expression of heat shock proteins 70 was not elevated obviously after the synergetic therapy,thus to avoid the tumor thermal resistance and further improve the therapeutic effect.The in vivo anti-tumoral performance of the BMNSs was further studied and complete tumor eradication was achieved without any recurrence and biotoxicity.Not only demonstrating a paradigm of high therapeutic efficacy of mild hyperthermia and synergistic chemotherapy for precise cancer therapy,our findings proved that the cancer therapeutic effect can be improved with minimal side effects through exquisite designing of the microstructures and the physiochemical properties of the nanoplatform.

关 键 词：mild hyperthermia MoSe_(2)/Bi_(2)Se_(3)nanosaucers thermal resistance heat shock proteins 70 

分 类 号：R730.53[医药卫生—肿瘤]