Emerging prospects of protein/peptide-based nanoassemblies for drug delivery and vaccine development  

作　　者：Taiyu Liu Lu Li Cheng Cheng Bingfang He Tianyue Jiang 

机构地区：[1]School of Pharmaceutical Sciences,Nanjing Tech University,Nanjing 211816,China

出　　处：《Nano Research》2022年第8期7267-7285,共19页纳米研究（英文版）

基　　金：the National Key Research and Development Program of China(No.2019YFA0905200);the National Natural Science Foundation of China(No.82072045);the Natural Science Foundation of Jiangsu Province of China for Excellent Young Scholars(No.BK20190084).

摘　　要：Proteins have been widely used in the biomedical field because of their well-defined architecture,accurate molecular weight,excellent biocompatibility and biodegradability,and easy-to-functionalization.Inspired by the wisdom of nature,increasing proteins/peptides that possess self-assembling capabilities have been explored and designed to generate nanoassemblies with unique structure and function,including spatially organized conformation,passive and active targeting,stimuli-responsiveness,and high stability.These characteristics make protein/peptide-based nanoassembly an ideal platform for drug delivery and vaccine development.In this review,we focus on recent advances in subsistent protein/peptide-based nanoassemblies,including protein nanocages,virus-like particles,self-assemblable natural proteins,and self-assemblable artificial peptides.The origin and characteristics of various protein/peptide-based assemblies and their applications in drug delivery and vaccine development are summarized.In the end,the prospects and challenges are discussed for the further development of protein/peptide-based nanoassemblies.

关 键 词：drug delivery VACCINE protein/peptide SELF-ASSEMBLY targeting controlled release 

分 类 号：TB383[一般工业技术—材料科学与工程]