养血清脑丸联合度洛西汀治疗卒中后抑郁的临床效果及对神经介质水平的影响研究  

Clinical Effect of Yangxue Qingnao Pill(养血清脑丸)Combined with Duloxetine in Treatment of Poststmke Depression Disorder and Its Influence on Neuromedium

作　　者：陈妍[1] 梁玉婵[1] 陈东梅[1] 伍志焕 CHEN Yan;LIANG Yuchan;CHEN Dongmei;WU Zhihuan(The First People's Hospital of Zhaoqing,Zhaoqing 526200,Guangdong,China)

机构地区：[1]肇庆市第一人民医院,广东肇庆526200

出　　处：《辽宁中医杂志》2022年第8期107-109,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：肇庆市科技计划项目(202004030722);广东省中医药管理局建设中医药强省科研基金项目(20121003)。

摘　　要：目的探究养血清脑丸联合度洛西汀在卒中后抑郁障碍中的效果及对神经介质水平的影响。方法回顾2020年10月—2021年4月本院收治卒中后抑郁障碍患者选择68例的临床资料,按照治疗方法分组,两组患者病例数都是34例,分别为对照组及观察组。对照组给予基础治疗+度洛西汀,观察组给予基础治疗+度洛西汀+养血清脑丸,对比两组患者汉密尔顿抑郁量表(HAMD)、血清5-HT、NE水平变化及药品不良反应。结果两组患者治疗4周、8周、停药2周后HAMD评分均较治疗前明显降低(P<0.05),且观察组HAMD评分明显低于对照组(P<0.05),HAMD疗效总有效率也较对照组高[82.35%(28/34)vs 67.65%(23/34),P<0.05];两组患者经治疗4周、8周后血清5-HT和NE水平较治疗前升高,观察组和对照组组内治疗前后对比P<0.05,而且观察组血清5-HT和NE水平高于对照组,且P<0.05;两组发生药品不良反应与对照组无差异[8.82%(3/34)vs 11.76%(4/34),P>0.05]。结论养血清脑丸联合度洛西汀在患者中应用,能够改善5-HT和NE水平,改善患者神经介质水平,同时降低HAMD程度,提升HAMD疗效,可积极采纳。Objective To explore the effect of Yangxue Qingnao Pill(养血清脑丸)combined with duloxetine inpoststmke depression disorderand its influence on the level of nerve mediators.Method The clinical data of 68 patients with post-stroke depression admitted to the hospital from October 2020 to April 2021 were reviewed.According to the treatment methods,the number of patients in both groups was 34,which were the control group and the observation group,respectively.The control group was given basic treatment+duloxetine,and the observation group was given basic treatment+duloxetine+Yangxue Qingnao Pill.The changes of Hamilton Depression Scale(HAMD),serum levels of 5-hydroxytryptamine(5-HT),norepinephrine(NE)and adverse drug reactions in two groups were compared.Results The HAMD scores of the two groupsafter treatment for 4 and 8 weeksand 2 weeks of drug withdrawal were significantly lower than those before treatment(P<0.05),and the HAMD score of the observation group was significantly lower than that of the control group(P<0.05).The effective rate was also higher than that of the control group[82.35%(28/34)vs 67.65%(23/34),P<0.05].The serum levels of 5-HT and NE of the two groupsafter 4 and 8 weekswere higher than those before treatment.The comparison between the observation group and the control group before and after treatment was not significant(P<0.05).The serum levels of 5-HT and NE of the observation group were higher than those of the control group(P<0.05).There was no difference in adverse drug reactions between the two groups and the control group[8.82%(3/34)vs 11.76%(4/34),P>0.05].Conclusion The application of Yangxue Qingnao Pillcombined with duloxetine in PSD patients can improve the levels of 5-HT and NE,improve the levels of nerve mediators in patients,reduce the degree of HAMD and improve the efficacy of HAMD.It can be actively adopted.

关 键 词：度洛西汀 养血清脑丸 卒中后抑郁障碍 神经介质水平 

分 类 号：R743.3[医药卫生—神经病学与精神病学]