扶正抑瘤汤对原发性肝癌根治切除术患者术后复发及血管肿瘤标志物水平的影响观察  

Effect of Fuzheng Yiliu Decoction(扶正抑瘤汤)on Postoperative Recurrence and Vascular Tumor Markers in Patients with Primary Hepatocellular Carcinoma Undergoing Radical Resection

作　　者：尹全金 王岩[1,2] 徐磊 李忠廉[1,2] YIN Quanjin;WANG Yan;XU Lei;LI Zhonglian(Tianjin Medical University,Tianjin 300203,China;Affiliated Hospital of Nankai University(Tianjin Fourth Hospital),Tianjin 300222,China)

机构地区：[1]天津医科大学,天津300193 [2]南开大学附属医院(天津市第四医院),天津300222

出　　处：《辽宁中医杂志》2022年第8期133-135,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：天津市科委重点项目(10ZCGYSF00500)。

摘　　要：目的观察扶正抑瘤汤对原发性肝癌根治切除术患者术后复发及血管肿瘤标志物水平的影响。方法纳入2016年1月—2017年12月收治的80例原发性肝癌根治术患者作为研究对象,应用电脑双盲法分为对照组和观察组,每组40例。两组患者均给予肝癌根治术进行治疗,术后对照组给予常规放化疗治疗,观察组则在对照组基础上给予扶正抑瘤汤进行治疗,两组患者均进行连续3年的随访,对其术后生存率、复发情况进行观察,同时观察两组治疗前后血管肿瘤标志物水平和治疗过程中不良反应发生情况。结果观察两组患者术后生存率及复发情况发现,两组患者术后1年和2年的生存率差异无统计学意义(P>0.05),术后3年观察组生存率高于对照组,且观察组术后复发率低于对照组,组间差异有统计学意义(P<0.05)。观察两组治疗前后血管肿瘤标志物水平发现,治疗前两组各指标间差异无统计学意义(P>0.05),治疗后观察组的AFP(甲胎蛋白)、CEA(外周血癌胚抗原)及DCP(人血清异常凝血酶原)均低于对照组,组间差异有统计学意义(P<0.05)。观察两组患者治疗过程中不良反应发生情况发现,观察组总发生率低于对照组,组间差异有统计学意义(P<0.05)。结论研究发现,扶正抑瘤汤在原发性肝癌根治切除术患者术后治疗中应用效果良好,可有效地延长患者生存期,降低术后复发风险,改善患者血管肿瘤标志物水平,提高临床治疗的有效性,同时还可减少患者治疗不良反应的发生,提高治疗安全性。Objective To observe the effect of Fuzheng Yiliu Decoction(扶正抑瘤汤)on postoperative recurrence and vascular tumor markers in patients with primary liver cancer after radical resection.Methods A total of 80 patients with primary liver cancer undergoing radical resection from January 2016 to December 2017 were included as the research subjects and were divided into control group and observation group by computer double-blind method,with 40 patients in each group.Patients in both groups were treated with radical resection of liver cancer.The control group was treated with conventional radiotherapy and chemotherapy after surgery and the observation group was treated with Fuzheng Yiliu Decoction on the basis of the control group.Patients in both groups were followed up for 3 consecutive years,and their postoperative survival rate and recurrence were observed.The levels of vascular tumor markers before and after treatment and the incidence of adverse reactions during treatment were observed in both groups.Results The postoperative survival rate and recurrence of the two groups were observed,and there was no significant difference in the 1 or 2 year postoperative survival rate between the two groups(P>0.05).The survival rate of the observation group was higher than that of the control group 3 years after surgery and the postoperative recurrence rate of the observation group was lower than that of the control group and the difference between the groups was significant(P<0.05).The levels of vascular tumor markers before and after treatment in the two groups showed no significant differences(P>0.05).The levels of AFP(alpha-fetoprotein),CEA(peripheral blood carcinoembryonic antigen)and DCP(human serum abnormal prothrombin)in the observation group were lower than those in the control group after treatment,and the differences were significant(P<0.05).The incidence of adverse reactions in two groups during treatment was observed,and the total incidence of adverse reactions in observation group was lower than that in co

关 键 词：扶正抑瘤汤 原发性肝癌 肝癌根治术 术后复发 血管肿瘤标志物水平 

分 类 号：R735.7[医药卫生—肿瘤]