枳实通降颗粒对开腹直肠癌术后患者血清炎症因子白细胞介素-6、白细胞介素-8及肿瘤坏死因子-α水平及胃肠功能恢复的影响  

The effect of the Zhishi Tongjiang granules on serum IL-6,IL-8 and TNF-αlevels and its influence on the recovery of gastrointestinal function in postoperative patients with rectal cancer

作　　者：莫黎[1] 康安定[2] 谢彪[1] 武明胜[3] 曾娟妮[1] 周平兰[1] 吴俪珧 王华帅 何永恒 MO Li

机构地区：[1]湖南中医药大学第二附属医院,湖南长沙410005 [2]湖南省肿瘤医院,湖南长沙410006 [3]湖南省中医药研究院附属医院,湖南长沙410006 [4]湖南中医药大学,湖南长沙410208

出　　处：《中医临床研究》2022年第23期54-57,共4页Clinical Journal Of Chinese Medicine

基　　金：湖南中医药大学中医学国内一流建设学科开放基金(2018ZYX18);湖南省中医药管理局一般课题(2021100);长沙市自然科学基金项目(kq20142017);湖南省自然科学基金面上项目(2021JJ30518)。

摘　　要：目的:研究枳实通降颗粒对开腹直肠癌根治性切除术后患者血清炎症因子、炎症指标、D-二聚体及胃肠功能恢复的影响。方法:将60例患者随机分为两组,每组30例,术后均给予常规治疗措施。术后6~12 h开始,治疗组给予枳实通降颗粒口服,而对照组则予同体积安慰剂口服,疗程为4 d。比较两组患者术后胃肠功能恢复情况及术后第1天、第3天、第5天白细胞计数及血清中C-反应蛋白、降钙素原、D-二聚体、白细胞介素-6、白细胞介素-8及肿瘤坏死因子-α水平的变化。结果:治疗组胃肠功能恢复指标均优于对照组(P<0.01);术后第1天,治疗组白细胞介素-6及肿瘤坏死因子-α水平低于对照组(P<0.05),但其他各项指标的差异无统计学意义(P>0.05);术后第3天、第5天,治疗组白细胞计数、C-反应蛋白、降钙素原、D-二聚体、白细胞介素-6、白细胞介素-8及肿瘤坏死因子-α水平均显著低于对照组(P<0.01);在肺部感染发生率方面,两组的差异无统计学意义(P>0.05);但在总并发症发生率方面比较,两组的差异有统计学意义(P<0.05)。结论:枳实通降颗粒能显著降低开腹直肠癌术后患者血清中炎症因子、炎症指标及D-二聚体的水平,改善机体血液的高凝状态,有效促进术后患者胃肠功能恢复,防治术后炎性肠梗阻。Objective:To study the effect of the Zhishi Tongjiang granules(枳实通降颗粒)on serum inflammatory factors,inflammatory indexes,D-dimer and gastrointestinal function recovery of postoperative patients with rectal cancer.Methods:A total of 60 cases were randomly divided into two groups,with 30 cases in each group.Routine treatments were given postoperatively in both groups.From 6 to 12 hours after operation,the treatment group was given the Zhishi Tongjiang granules orally,while the control group was given the same volume of placebo orally,and the course of treatment was 4 days.Results:The indexes of gastrointestinal function recovery in the treatment group were better than the control group(P<0.01).On the first day after operation,the levels of interleukin-6 and tumor necrosis factor-αin the treatment group were lower than those in the control group(P<0.05),but there was no significant difference in other indicators(P>0.05).On the 3rd and 5th days after operation,the levels of leukocyte,C-reactive protein,procalcitonin,D-dimer,interleukin-6,interleukin-8 and tumor necrosis factor-αin the treatment group were all significantly lower than those in the control group(P<0.01).There was no significant difference in the incidence of pulmonary infection between the two groups(P>0.05).However,there was a statistically significant difference in the incidence of total complications between the two groups(P<0.05).Conclusion:The Zhishi Tongjiang granules can significantly reduce the levels of inflammatory factors,inflammatory indicators and D-dimer in serum of postoperative patients with rectal cancer,relieve the hypercoagulable state of the body,effectively promote the recovery of gastrointestinal function,and prevent postoperative inflammatory ileus.

关 键 词：直肠癌 术后炎性肠梗阻 炎症因子 枳实通降颗粒 

分 类 号：R73[医药卫生—肿瘤]