喹硫平联合颅磁刺激治疗老年痴呆精神行为症状的临床效果  

Clinical Effect of Quetiapine Combined with Cranial Magnetic Stimulation in the Treatment of Mental and Behavioral Symptoms of Senile Dementia

作　　者：高丽红 GAO Lihong(Department of Neurology,Lijin County Central Hospital,Dongying,Shandong Province,257400 China)

机构地区：[1]利津县中心医院神经内科,山东东营257400

出　　处：《系统医学》2022年第16期124-127,共4页Systems Medicine

摘　　要：目的 针对老年痴呆精神行为症状选择喹硫平及颅磁刺激联合治疗方案的临床效果及安全性进行分析。方法 选取2020年1—10月在利津县中心医院接受治疗的老年痴呆精神行为症状患者90例,以随机数表法分为对照组和观察组,各45例。对照组选择喹硫平治疗,观察组在用药基础上联合颅磁刺激治疗,对比不同治疗方案的临床效果、安全性及患者预后差异。结果 观察组治疗有效率97.78%高于对照组82.22%,差异有统计学意义(χ^(2)=4.444,P=0.035);治疗后,观察组认知功能、生活活动能力和智力水平评分较对照组高,精神行为症状评分较对照组低,差异有统计学意义(P<0.05);对照组不良反应发生率11.11%略高于观察组6.67%,但差异无统计学意义(χ^(2)=0.137,P=0.711)。结论 老年痴呆患者伴有精神行为症状在服用喹硫平治疗的同时联合实施颅磁刺激进行治疗,可提升治疗总体有效性,联合方案安全性理想,应用价值显著。Objective To analyze the clinical effect and safety of quetiapine combined with cranial magnetic stimulation for mental and behavioral symptoms of senile dementia.Methods A total of 90 patients with senile dementia with mental and behavioral symptoms who were treated in Lijin County Central Hospital from January to October 2020were selected and randomly divided into control group and observation group, with 45 cases in each group. The control group was treated with quetiapine, and the observation group was treated with cranial magnetic stimulation on the basis of medication. The clinical efficacy, safety and prognosis of patients were compared among different treatment regimens.Results The treatment effective rate of the observation group was 97.78% higher than that of the control group,82.22%, and the difference was statistically significant(χ^(2)=4.444, P=0.035). After treatment, the scores of cognitive fuctional, life activity ability and intelligence level of the observation group were higher than those of the control group, and the scores of mental and behavioral symptoms were lower than those of the control group, and the differences were statistically significant(P<0.05). The incidence of adverse reactions in the control group was 11.11%,which was slightly higher than that in the observation group, 6.67%, but the difference was not statistically significant(χ^(2)=0.137, P=0.711).Conclusion The combined treatment of quetiapine combined with cranial magnetic stimulation can improve the overall effectiveness of the treatment in senile dementia patients with mental and behavioral symptoms. The combined regimen is safe and has significant application value.

关 键 词：喹硫平 颅磁刺激 老年痴呆 精神行为症状 

分 类 号：R749.16[医药卫生—神经病学与精神病学]