水凝胶在生物医学领域的研究进展  

Research progress of hydrogels in biomedicine

作　　者：吴维 吴迪[1] 马珊珊 汤春波[1] WU Wei;WU Di;MA Shanshan;TANG Chunbo(Jiangsu Key Laboralory of Oral Diseases,Nanjing Medical Universily,Department of Dental Implant and Prosthodontics,Afiliated Hospial of Stomalology,Nanjing Medical University,Jiangsu Prorince Engineering Re-search Center of Stomatological Translational Medicine,Nanjing 210029,China)

机构地区：[1]南京医科大学口腔疾病研究江苏省重点实验室,南京医科大学附属口腔医院种植修复科,江苏省口腔转化医学工程研究中心,江苏南京210029

出　　处：《口腔医学》2022年第9期831-837,共7页Stomatology

基　　金：国家自然科学基金(82170993);国际科技合作计划(2018YFE0194100);东大-南医大合作研究项目(2242018K3DN03)。

摘　　要：水凝胶是在水溶液中通过化学和/或物理交联而形成的三维网络聚合物。水凝胶常具有高吸水性和保水性,它高度水合的性质与细胞外基质类似,这赋予了水凝胶极好的生物相容性;除此之外,许多水凝胶还具有抗炎、抗氧化、抗癌等生物功能,因此水凝胶具有应用于生物医学领域的巨大潜力。目前,水凝胶在组织工程支架、药物载体以及生物医学装置中都发挥着重要作用。该文介绍了水凝胶的基本性质及在生物医学领域中常用的水凝胶,重点综述水凝胶在生物医学领域中的应用,并总结水凝胶应用的现状及在进一步临床转换过程中需要克服的一些问题。Hydrogel is a three-dimensional network polymer formed by chemical and/or physical crosslinking in aqueous solution. Hydrogels often have high water absorption and water retention, and their highly hydrated properties are similar to those of extracellular matrix, which endows hydrogels with excellent biocompatibility. In addition, many hydrogels have biological functions such as anti-inflammatory, anti-oxidation and anti-cancer, so hydrogels have great potential for application in biomedicine. At present, hydrogels play an important role in tissue engineering scaffolds, drug carriers and biomedical devices. In this paper, basic properties of hydrogels and hydrogels commonly used in biomedicine are introduced, and the application of hydrogels in biomedicine is emphasized. Present situation of its application is summarized, and problems to be overcome in further clinical transformation of hydrogels are discussed.

关 键 词：水凝胶 组织工程 药物载体 

分 类 号：R783.1[医药卫生—口腔医学]