基于美容效果及生命质量探究早期乳腺癌手术患者术中放疗和术后放疗的效果  

Effect of intraoperative radiotherapy and postoperative radiotherapy in patients undergoing early breast cancer surgery investigated based on cosmetic effect and quality of life

作　　者：朱成斌[1] 茅芯慧 祁小丽[1] ZHU Chengbin;MAO Xinhui;QI Xiaoli(Radiotherapy Center,People’s Hospital of Xinjiang Uygur Autonomous Region,Xinjiang,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院放疗中心,新疆乌鲁木齐830001

出　　处：《中国医药科学》2022年第18期139-142,共4页China Medicine And Pharmacy

摘　　要：目的研究术中放疗及术后放疗对早期乳腺癌手术患者生命质量及美容效果的影响。方法纳入2017年3月至2020年2月新疆维吾尔自治区人民医院放疗中心接纳的早期乳腺癌患者92例,所有患者均进行保乳手术及放疗治疗,回顾性分析患者临床资料,根据患者不同放疗时间进行分组,其中常规术后放疗42例患者纳入术后组,术中放疗50例患者纳入术中组,评估两组患者术前及术后3个月生命质量及美容效果,记录放疗相关并发症,随访2年,统计患者生存率。结果术中组美容优良率高于术后组,差异有统计学意义(P<0.05);术后3个月术中组生命质量4项评分均高于术后组,差异有统计学意义(P<0.05);术中组放射性皮炎、放射性疼痛、色素沉着发生率低于对照组,差异有统计学意义(P<0.05);随访2年,术中组术后1年及2年无进展生存率、总生存率与术后放疗组比较,差异无统计学意义(P>0.05)。结论临床早期乳腺癌患者术中放疗与术后放疗的选择不影响患者2年生存率,但术中放疗可显著提高美容效果及患者的生命质量,减少放疗并发症。Objective To investigate the impacts of intraoperative radiotherapy and postoperative radiotherapy in patients undergoing early breast cancer surgery on quality of life(QoL)and cosmetic effect.Methods A total of 92 patients with early breast cancer admitted to the Radiotherapy Center of People’s Hospital of Xinjiang Uygur Autonomous Region from March 2017 to February 2020 were enrolled.All patients were treated with breast-conserving surgery and radiotherapy.The clinical data of patients were retrospectively analyzed and the patients were divided into the postoperative group(n=42)and the intraoperative group(n=50)according to different radiotherapy times.The postoperative group was treated with conventional postoperative radiotherapy,while the intraoperative group was treated with intraoperative radiotherapy.The QoL and cosmetic effect of patients in the two groups were evaluated before and 3 months after surgery.The radiotherapy-related complications were recorded.The patients were followed up for 2 years and the survival rate was counted.Results The excellent rate of cosmetic rate in the intraoperative group was higher than that in the postoperative group,with statistically significant difference(P<0.05).3 months after operation,the scores of 4 items of QoL in the intraoperative group were all higher than those in the postoperative group,with statistically significant differences(P<0.05).The incidences of radiodermatitis,radiating pain and pigmentation in the intraoperative group were lower than those in the control group,with statistically significant differences(P<0.05).After 2 years of follow-up,there were no statistically significant differences in 1-year and 2-year progression free survival rates and the overall survival rates between the intraoperative group and the postoperative radiotherapy group(P>0.05).Conclusion The choice of intraoperative radiotherapy and postoperative radiotherapy does not impact the 2-year survival rate of patients with early breast cancer.However,intraoperative radiotherapy ca

关 键 词：乳腺癌 保乳手术 放疗 生命质量 生存率 

分 类 号：R737.9[医药卫生—肿瘤]