超早期经胃管注入清胰汤对高三酰甘油血症急性胰腺炎患者的疗效  

Therapeutic efficacy of ultra-early injection of Qingyi Decoction through gastric tube on patients with hypertriglyceridemiainduced acute pancreatitis

作　　者：叶浩 易晓雷 YE Hao;YI Xiaolei(Department of Hepatobiliary and Pancreatic Surgery,Changsha Hospital of Traditional Chinese Medicine(Changsha Eighth Hospital),Hunan,Changsha 410100,China)

机构地区：[1]长沙市中医医院(长沙市第八医院)肝胆胰外科,湖南长沙410100

出　　处：《中国医药科学》2022年第17期193-196,共4页China Medicine And Pharmacy

摘　　要：目的探讨超早期经胃管注入清胰汤对高三酰甘油血症急性胰腺炎(HTGAP)患者的疗效。方法选取长沙市中医医院(长沙市第八医院)2018年6月至2020年12月收治的150例HTGAP患者为研究对象,采用随机数表法分成A、B、C三组,每组各50例。所有患者均给予综合治疗,包括禁食、胃肠减压等。A组不经胃管注药,B组、C组分别于入院后24 h内、入院后第3天经胃管注入清胰汤。入院当天及治疗后12 d取患者空腹静脉血,比较三组临床疗效,比较三组腹痛消失时间、开始进食时间、住院时间,比较三组患者治疗前后三酰甘油(TG)、降钙素原(PCT)、C-反应蛋白(CRP)、纤维蛋白原、D-二聚体、缺氧诱导因子1α(HIF-1α)水平。结果治疗后,B组临床疗效显著优于A、C组(P<0.05);B组腹痛消失时间、开始进食时间、住院时间均明显短于A、C组(P<0.05);三组TG均显著下降(P<0.05),但PCT、CRP、纤维蛋白原、D-二聚体、HIF-1α均明显升高(P<0.05),且B组上述各指标均较A、C组显著降低(P<0.05)。结论超早期经胃管注入清胰汤可降低血清TG、改善高凝状态、降低HIF-1α水平及减轻炎症反应,缓解HTGAP病情。Objective To investigate the application efficacy of ultra-early injection of Qingyi Decoction through gastric tube on patients with hypertriglyceridemia-induced acute pancreatitis(HTGAP).Methods A total of 150 patients with HTGAP admitted to and treated in Changsha Hospital of Traditional Chinese Medicine(Changsha Eighth Hospital)from June 2018 to December 2020 were selected as the research subjects.They were divided into group A(n=50),group B(n=50)and group C(n=50)according to the random number table method.All patients were given comprehensive treatment,including fasting,gastrointestinal decompression,etc.For patients in group A,drugs were not injected through gastric tube,while for patients in group B and group C,Qingyi Decoction was injected through gastric tube within 24 hours and 3 days after admission,respectively.Fasting venous blood was taken on the day of admission and 12 days after treatment,and the clinical efficacies of the three groups were compared.The disappearance time of abdominal pain,the start time of eating and the hospitalization time of the three groups were compared among the three groups.The levels of triglyceride(TG),procalcitonin(PCT),C-reactive protein(CRP),fibrinogen,D-dimer and hypoxia-inducible factor 1α(HIF-1α)of patients in the three groups were compared before and after treatment.Results After treatment,the clinical efficacy of group B was significantly superior to that of group A and group C(P<0.05);the disappearance time of abdominal pain,the start time of eating and the hospitalization time in group B were all significantly shorter than those in group A and group C(P<0.05);the TG of patients in the 3 groups all decreased significantly(P<0.05),while PCT,CRP,fibrinogen,D-dimer and HIF-1αall increased significantly(P<0.05),and all the above indices in group B were significantly lower than those in group A and group C(P<0.05).Conclusion Ultra-early injection of Qingyi Decoction through gastric tube can reduce serum TG,improve hypercoagulable state,reduce HIF-1αlevel,relieve i

关 键 词：高三酰甘油血症急性胰腺炎 三酰甘油 缺氧诱导因子1Α 高凝状态 清胰汤 

分 类 号：R576[医药卫生—消化系统] R259[医药卫生—内科学]