Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds  

作　　者：MONALISA MISHRA PUNYATOYA PANDA BEDANTA KUMAR BARIK AMRITA MONDAL MRUTUNJAYA PANDA 

机构地区：[1]Neural Developmental Biology Lab,Department of Life Science,NIT Rourkela,Rourkela,769008,India [2]Centre for Nanomaterials,NIT Rourkela,Rourkela,769008,India

出　　处：《BIOCELL》2023年第1期51-69,共19页生物细胞（英文）

基　　金：MM Lab is supported by SERB/EMR/2017/003054,BT/PR21857/NNT/28/1238/2017;Odisha DBT 3325/ST(BIO)-02/2017.

摘　　要：Exposure to some toxic compounds causes structural and behavioral anomalies associated with the neurons in the later stage of life.Those toxic compounds are termed as a neurotoxicant,which can be a physical factor,a toxin,an infection,radiation,or maybe a drug.The incongruities caused due to a neurotoxicant further depend on the toxicity of the compound.More importantly,the neurotoxicity of the compound is associated with the concentration and the time point of exposure.The neurodevelopmental defect appears depending on the toxicity of the compound.A neurodevelopmental defect may be associated with a delay in developmental time,defective growth,structural abnormality of many organs,including sensory organs,behavioral abnormalities,or death in the fetus stage.Numerous model organisms are employed to assess the effect of neurotoxicants.The current review summarizes several methods used to check the effect of neurotoxicant and their effect using the model organism Drosophila melanogaster.

关 键 词：Developmental cycle Drug metabolism NEUROTOXICITY Neurotoxicants Complex behavioral assay Stress enzymes 

分 类 号：Q42[生物学—神经生物学]