视黄酸受体相关孤儿受体α在肿瘤发生发展中的作用研究进展  

Research progress on the role of retinoic acid receptor-related orphan receptorαin tumorigenesis and development

作　　者：徐凡 郭方圆 何燕[1] 魏向群 XU Fan;GUO Fangyuan;HE Yan;WEI Xiangqun(Department of Gynecology,the Affliated Hospital of Yunnan University,Kunming Yunnan 65000,P.R.China)

机构地区：[1]云南大学附属医院妇科,昆明650000

出　　处：《华西医学》2022年第9期1419-1423,共5页West China Medical Journal

基　　金：云南省万人计划-名医计划项目(YNWR-MY-2020-060);广东省至善妇儿健康关爱基金会“电生理适宜技术推广”专项([2019]03073)。

摘　　要：视黄酸受体相关孤儿受体α(retinoic acid receptor-related orphan receptorα,RORα)作为核受体超家族成员,通过调控相关基因的表达,参与多种病理生理过程。RORα在生物节律、代谢、血管增生及炎症等方面发挥重要的作用,而这些方面又与肿瘤的发生发展关系密切。该综述主要讨论RORα的生物学特征及其在肿瘤发生发展中的作用及机制,为肿瘤相关研究提供新的思路。As a member of the nuclear receptor superfamily,retinoic acid receptor-related orphan receptorα(RORα)is involved in a variety of pathophysiological processes by regulating the expression of related genes.RORαplays an important role in biological rhythm,metabolism,vascular hyperplasia and inflammation,which are closely related to the occurrence and development of tumors.This review focuses on the biological characteristics of RORαand its role and mechanism in tumorigenesis and development,so as to provide new ideas for tumor-related research.

关 键 词：视黄酸受体相关孤儿受体α 肿瘤 基因调控 

分 类 号：R730.2[医药卫生—肿瘤]