颞上视网膜分支静脉阻塞继发黄斑水肿患眼脉络膜厚度改变  

Changes of choroidal thickness in patients with superior temporal branch retinal vein occlusion complicated with macular edema

作　　者：许雪妹[1] 关利莹 郭立涛[1] 苏锐锋[1] 邓志鸿[1] 石晶[1] Xu Xuemei;Guan Liying;Guo Litao;Su Ruifeng;Deng Zhihong;Shi Jing(Department of Ophthalmology,The Affiliated Hospital of Chengde Medical College,Chengde 067000,China)

机构地区：[1]承德医学院附属医院眼科,承德067000

出　　处：《中华眼底病杂志》2022年第9期750-754,共5页Chinese Journal of Ocular Fundus Diseases

基　　金：承德市科学技术研究与发展计划(202006A038)。

摘　　要：目的观察颞上视网膜分支静脉阻塞继发黄斑水肿(BRVO-ME)患眼脉络膜厚度变化特征。方法回顾性对照研究。2020年11月至2021年9月于承德医学院附属医院眼科检查确诊的颞上BRVO-ME患者30例30只眼(BRVO-ME组)和同期健康志愿者14名28只眼(对照组)纳入研究。采用频域光相干断层扫描的增强深部成像技术测量受检眼黄斑区脉络膜厚度。根据糖尿病视网膜病变治疗研究组分区将黄斑中心凹6 mm范围内脉络膜划分为以黄斑中心凹为中心的3个同心圆,分别是直径为1 mm的中心区,1~3 mm的内环区,3~6 mm的外环区;内环区和外环区分别划分为上方、下方、鼻侧、颞侧,并分别记作S3、I3、N3、T3和S6、I6、N6、T6,共计9个区。观察两组受检眼不同区域脉络膜厚度的分布特点。两组间黄斑不同分区脉络膜厚度比较行独立样本t检验。结果对照组、BRVO-ME组受检眼中心区、S3、T3、I3、N3、S6、T6、I6、N6脉络膜厚度分别为(214.11±56.04)、(207.89±57.92)、(214.07±54.82)、(207.14±61.54)、(180.18±53.53)、(204.25±59.60)、(193.93±51.50)、(190.54±51.21)、(139.82±39.84)μm和(258.00±71.14)、(256.43±68.70)、(252.07±72.97)、(244.37±68.49)、(243.10±70.93)、(247.20±68.36)、(221.00±61.28)、(223.77±58.64)、(183.20±60.15)μm。两组受检眼脉络膜厚度均以中心区最厚,至鼻侧、颞侧逐渐变薄;鼻侧脉络膜厚度较其他分区变薄更明显,以N6区最薄。与对照组比较,BRVO-ME组患眼中心区、S3、T3、I3、N3、S6、I6、N6脉络膜增厚,差异有统计学意义(t=-2.899、-2.229、-2.172、-3.250、-2.543、-2.292、-3.214,P<0.05);T6区差异无统计学意义(t=-1.814,P=0.075)。结论BRVO-ME患眼黄斑区脉络膜厚度较正常人增厚。Objective To observe the characteristics of choroidal thickness in patients with macular edema secondary to superior temporal branch retinal vein occlusion(BRVO-ME).Methods A retrospective control study.From November 2020 to September 2021,30 patients(30 eyes)with BRVO-ME(BRVO-ME group)were diagnosed by ophthalmology examination in Department of Ophthalmology,The Affiliated Hospital of Chengde Medical College and 14 healthy volunteers(28 eyes)were enrolled in the study.The choroidal thickness of macular area was measured by enhanced deep imaging technique of frequency domain optical coherence tomography.According to the subdivision of the diabetic retinopathy treatment group,the choroid within the 6 mm of the macular fovea was divided into three concentric circles with the macular fovea as the center,namely,the central area with the diameter of 1 mm,the inner ring of 1-3 mm and the outer ring of 3-6 mm.The inner ring area and the outer ring area are divided into upper,lower,nasal and temporal sides,respectively,which are denoted as S3,I3,N3,T3 and S6,I6,N6,T6,totaling 9 areas.To observe the distribution characteristics of choroidal thickness in different regions of two groups of eyes.The choroidal thickness of different macular regions was compared by independent sample t-test.Results The choroidal thicknesses in the central area,S3,T3,I3,N3,S6,T6,I6,and N6 of the eyes in the control group and BRVO-ME group were 214.11±56.04,207.89±57.92,214.07±54.82,207.14±61.54,180.18±53.53,204.25±59.60,193.93±51.50,190.54±51.21,139.82±39.84μm and 258.00±71.14,256.43±68.70,252.07±72.97,244.37±68.49,243.10±70.93,247.20±68.36,221.00±61.28,223.77±58.64,183.20±60.15μm.In both groups,the choroidal thickness was the thickest in the central area,gradually thinning to the nasal side and temporal side,and the nasal choroidal thickness was thinner than other regions,and N6 area was the thinnest.Compared with the control group,the choroidal thickness of central area,S3,T3,I3,N3,S6,I6 and N6 in BRVO-ME group were signif

关 键 词：视网膜静脉闭塞 黄斑水肿 脉络膜 体层摄影术 光学相干 

分 类 号：R774[医药卫生—眼科]