乳腺癌病灶与正常乳腺^(18)F-FDGPET-CT代谢参数差异对比研究  

Comparative Study on Differences of ^(18)F-FDGPET-CT Metabolic Parameters Between Breast Cancer Lesions and Normal Breast

作　　者：王警建 王媛媛[2] 李娜 WANG Jing-jian;WANG Yuan-yuan;LI Na(Department of Imaging,Ninth Hospital of Xi'an,Xi'an 710054,Shaanxi Province,China;Department of Breast Surgery,Yan'anPeople's Hospital,Yan'an 716000,Shaanxi Province,China;CT/MRI Room,Ninth Hospital of Xi'an,Xi'an 710054,Shaanxi Province,China)

机构地区：[1]西安市第九医院影像科,陕西西安710054 [2]陕西省延安市人民医院乳腺外科,陕西延安716000 [3]西安市第九医院CT/MRI室,陕西西安710054

出　　处：《中国CT和MRI杂志》2022年第10期66-68,共3页Chinese Journal of CT and MRI

摘　　要：目的研究乳腺癌病灶与正常乳腺^(18)F-脱氧葡萄糖(^(18)F-FDG)正电子发射断层扫描(PET)-CT代谢参数差异。方法回顾性分析2018.1至2019.12我院收治的45例乳腺癌患者临床资料为研究对象,另选取35例乳腺良性肿瘤患者的临床资料为对照组,将病理检查结果作为金标准,比较^(18)F-FDGPET-CT的诊断结果,比较两组^(18)F-FDGPET-CT代谢参数[最大标准摄取值(SUV_(max))、代谢体积(MTV)、糖酵解总量(TLG)]。结果^(18)F-FDGPET-CT与病理检查在诊断乳腺癌方面具有较高一致性(Kappa=0.950),灵敏度为95.56%,特异度为100.00%,准确率为97.50%,阳性预测率为100.00%,阴性预测率为94.59%。研究组^(18)F-FDGPET-CT代谢参数中的SUVmax、MTV、TLG均明显高于对照组(P<0.05)。结论^(18)F-FDGPET-CT在乳腺癌诊断中具有较好临床价值,乳腺癌病灶^(18)F-FDGPET-CT代谢参数与正常乳腺有较大差异,在临床诊断中具有一定价值。Objective To study the differences of ^(18)F-fluorodeoxyglucose(^(18)F-FDG)positron emission tomography(PET)-CT metabolic parameters between breast cancer lesions and normal breast.Methods The clinical data of 45 patients with breast cancer admitted to our hospital from January 2018 to December 2019 were retrospectively analyzed and set as study subjects,and the clinical data of another 35 patients with benign breast tumors were selected as control group.Using the pathological examination results as the gold standard,the diagnosis results of ^(18)F-FDG PET-CT were compared,and the ^(18)F-FDGPET-CT metabolic parameters[maximum standard uptake value(SUV_(max)),metabolic volume(MTV),total glycolysis(TLG)]were compared between the two groups.Results ^(18)F-FDGPET-CT and pathological examination had high consistency in the diagnosis of breast cancer(Kappa=0.950),and the sensitivity,specificity,accuracy rate,positive prediction rate and negative predictive rate were 95.56%,100.00%,97.50%,100.00%and 94.59%.The SUV_(max),MTV and TLG of ^(18)F-FDGPET-CT metabolic parameters in study group were significantly higher than those in control group(P<0.05).Conclusion ^(18)F-FDGPET-CT has good clinical value in the diagnosis of breast cancer.The ^(18)F-FDGPET-CT metabolic parameters in breast cancer lesions are quite different from those of normal breast,and have certain value in clinical diagnosis.

关 键 词：乳腺癌 ^(18)F-脱氧葡萄糖 正电子发射断层扫描 代谢参数 

分 类 号：R737.9[医药卫生—肿瘤]