脑出血后红细胞降解产物致继发性神经损伤的研究进展  

Recent advance in secondary nerve injury caused by erythrocyte degradation products after intracerebral hemorrhage

作　　者：覃军 熊金彪 胡继良 Qin Jun;Xiong Jinbiao;Hu Jiliang(Department of Neurosurgery,Laibin People's Hospital,Laibin 546100,China;Guangdong Engineering Research Center of Neuroanatomy Basic Research and Clinical Application,Department of Neurosurgery,Shenzhen People's Hospital,Shenzhen 518000,China)

机构地区：[1]广西来宾市人民医院神经外科,来宾546100 [2]深圳市人民医院神经外科,广东省神经解剖基础研究与临床应用工程技术研究中心,深圳518000

出　　处：《中华神经医学杂志》2022年第9期951-955,共5页Chinese Journal of Neuromedicine

摘　　要：脑出血是神经外科常见的急重症,具有较高的致残率和致死率。脑出血后红细胞裂解产物血红蛋白、胆红素、过氧化物酶等诱导的脑水肿、神经炎症等相关继发性损伤可能是患者预后不良和治疗的关键靶点,故本文围绕上述方向的最新研究进展综述如下,以期为脑出血的损伤机制研究及临床诊治提供新的思路。Intracerebral hemorrhage(ICH)is one of the most devastating diseases in neurosurgery with high mortality and morbidity.Brain edema,neuroinflammation and other related secondary injuries induced by red blood cell lysates such as hemoglobin,bilirubin and peroxidase after intracerebral hemorrhage may be key targets for poor prognosis and treatment;therefore,this article reviews the latest recent advance in the above contents as follows,in order to provide new ideas for the mechanism research and clinical diagnosis and treatment of patients with ICH.

关 键 词：脑出血 红细胞裂解产物 脑水肿 神经炎症 继发性损伤 

分 类 号：R743.34[医药卫生—神经病学与精神病学]