脑胶质瘤病人血浆miR-9-3p的变化及其与病人临床预后的关系  

Relationship between plasma level of miR-9-3p and survical pronosis of patients with glioma

作　　者：孙玉书[1] 王飞[2] 王振飞[3] 王选平 牟永平[3] SUN Yu-shu;WANG Fei;WANG Zhen-fei;WANG Xuan-ping;MU Yong-ping(Department of Oncology,Affiliated People's Hospital of Inner Mongolia Medical University(Inner Mongolia Cancer Hospital),Hohhot 010020,China;Department of Neurosurgery,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010010,China;Department of Tumor Molecular Diagnostic Laboratory,Affiliated People's Hospital of Inner Mongolia Medical University(Inner Mongolia Cancer Hospital),Hohhot 010020,China)

机构地区：[1]内蒙古医科大学附属人民医院暨内蒙古自治区肿瘤医院肿瘤内科,呼和浩特010020 [2]内蒙古医科大学附属医院神经外科,呼和浩特010010 [3]内蒙古医科大学附属人民医院暨内蒙古自治区肿瘤医院肿瘤分子诊断实验室,呼和浩特010020

出　　处：《中国临床神经外科杂志》2022年第8期653-655,共3页Chinese Journal of Clinical Neurosurgery

基　　金：呼和浩特市科技局基金项目(kjjxm201701);内蒙古医科大学致远人才项目(ZY0202036)。

摘　　要：目的探讨脑胶质瘤病人血浆miR-9-3p的变化及临床意义。方法选取2016年3月1日至2019年3月1日收治的脑胶质瘤42例,另选20例同期健康查体者为对照,用RT-PCR法检测血浆miR-9-3p水平。42例脑胶质瘤术后随访24~60个月,记录生存情况;以血浆miR-9-3p平均值为准,分为低表达和高表达。结果脑胶质瘤病人血浆miR-9-3p水平明显降低(P<0.05),多因素Cox分析显示,血浆miR-9-3P低表达是脑胶质瘤病人不良生存预后的独立危险因素(P<0.05)。生存曲线分析显示,miR-9-3p低表达脑胶质瘤病人中位总生存期较高表达病人明显缩短(P<0.05)。结论人脑胶质瘤血浆miR-9-3p表达下调,与病人不良生存预后密切相关。Objective To explore the relationship between plasma level of miR-9-3p and survical pronosis of patients with glioma.Methods The plasma level of miR-9-3p of 42 glioma patients and 20 health people(control group) were detected by real-time fluorescent quantitative PCR.The glioma patients were followed up for 24~60 months after operation,and their survival was recorded.According to the mean level of plasma miR-9-3p,the glioma patients were divided into low expression and high expression groups.Results The plasma level of miR-9-3p of glioma patients was significantly lower than control group(P<0.05).Multivariate Cox analysis showed that the low expression of plasma miR-9-3P was an independent risk factor for poor survival prognosis of glioma patients(P<0.05).Survival curve analysis showed that the median overall survival time of glioma patients in low expression group was significantly shorter than that of the glioma patients in high expression group(P<0.05).Conclusions The plasma miR-9-3p is down-regulated in human gliomas,Which is closely related to the poor survival prognosis of glioma patients.

关 键 词：脑胶质瘤 miR-9-3p 血浆水平 预后 

分 类 号：R739.41[医药卫生—肿瘤] R651.11[医药卫生—临床医学]