儿童急性淋巴细胞白血病长期化疗后生存质量评估  

Assessment of quality of life after long-term chemotherapy in childhood acute lymphoblastic leukemia

作　　者：赵迎春[1] 刘海港[2] Yingchun Zhao;Haigang Liu(Department of Pharmacy,Affiliated Hospital of Nantong University,Nantong 226001,China;Department of Medical Affairs,Affiliated Hospital of Nantong University,Nantong 226001,China)

机构地区：[1]南通大学附属医院临床药学科,江苏省南通市226001 [2]南通大学附属医院医务部,江苏省南通市226001

出　　处：《中国肿瘤临床》2022年第18期931-935,共5页Chinese Journal of Clinical Oncology

基　　金：南通市科技计划项目(编号:JCZ20024);南通市药学会-常州四药医院药学科研基金项目(编号:ntyx2001)资助。

摘　　要：目的:评估儿童急性淋巴细胞白血病(acute lymphocytic leukemia,ALL)经长期化疗后与健康相关的生存质量(health-re-lated quality of life,HRQL),并分析影响其部分的相关因素。方法:分析2013年1月至2019年6月在南通大学附属医院确诊为ALL的108例患儿临床资料,按照中国儿童白血病协作组(Chinese Children Leukemia Group,CCLG)-ALL-2008或中国儿童癌症协作组(Chinese Children Cancer Group,CCCG)-ALL-2015方案按序规范治疗,后随诊于南通大学附属医院。以健康儿童和同胞为双对照组,通过自设调查表和中文版儿童生存质量普适性核心量表(PedsQL 4.0)对ALL患儿进行调查分析。结果:ALL患儿的生存质量评分低于健康儿童组和同胞组,呈显著性差异(P<0.05)。患儿性格类型、家庭教育方式、填表时年龄、结束化疗后时间、确诊时危险分级为相关因素。结论:ALL患儿HRQL低于健康儿童组和同胞组,影响因素包括临床和社会学方面,应尽早筛查目标人群,针对性采取措施,提高其生存质量。Objective:To assess the health-related quality of life(HRQL)of childhood acute lymphocytic leukemia(ALL)after long-term chemotherapy and to analyze the relevant factors affecting their HRQL.Methods:From January 2013 to June 2019,we included 108 chil-dren with ALL,who were treated according to the Chinese Children Leukemia Group(CCLG)-ALL-2008 or Chinese Children Cancer Group(CCCG)-ALL-2015 protocols,followed-up in Affiliated Hospital of Nantong University.Healthy children and siblings were enrolled as dual con-trols.The children with ALL were asked to answer a self-administered questionnaire,and the pediatric quality of life inventory generic core scales version 4.0(PedsQL 4.0 scales)was used to analyze the patients.Results:The quality of life scores of children with ALL were signific-antly lower than those of healthy children and their siblings(P<0.05).The patients’personality type,family education style,age,time since the end of chemotherapy,and risk classification at the time of the diagnosis were associated factors.Conclusions:The quality of life of children with ALL was lower than that of healthy children due to clinical and sociological factors.Early screening and preventive meas-ures should be implemented among vulnerable populations to improve the patients'quality of life.

关 键 词：儿童 急性淋巴细胞白血病 与健康相关的生存质量 影响因素 

分 类 号：R733.71[医药卫生—肿瘤]