盐酸哌甲酯控释片单用与联合感觉统合训练对高功能孤独症谱系障碍共病注意缺陷多动障碍患儿的疗效  

Efficacy of methylphenidate hydrochloride controlled-release tablets alone and in combination with sensory integration training in children with high-functioning autism spectrum disorder and attention deficit hyperactivity disorder

作　　者：杜杨[1] DU Yang(Department of Psychology,Shenyang Children's Hospital,Shenyang 110032,China)

机构地区：[1]辽宁省沈阳市儿童医院心理科,110032

出　　处：《中国现代药物应用》2022年第17期180-183,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究盐酸哌甲酯控释片单用与联合感觉统合训练对高功能孤独症谱系障碍共病注意缺陷多动障碍患儿的疗效。方法50例高功能孤独症谱系障碍共病注意缺陷多动障碍患儿,依据随机分组法分为实验组和对照组,每组25例。对照组单纯应用盐酸哌甲酯控释片治疗,实验组在对照组基础上联合感觉统合训练。比较两组患儿治疗前后的视听整合持续性操作测试(IVA-CPT)结果、注意缺陷多动障碍评定量表(ADHD-RS-Ⅳ)评分,治疗后的孤独症行为评定量表(ABC)评分。结果治疗后,实验组IVA-CPT中的综合反应控制商数(FRCQ)(109.50±24.41)、综合注意力商数(FAQ)(99.41±20.66)均高于对照组的(97.30±15.31)、(88.65±10.01),差异具有统计学意义(P<0.05)。治疗后,实验组ADHD-RS-Ⅳ中的注意缺陷症状评分(13.01±3.60)分、多动冲动症状评分(13.49±6.31)分均低于对照组的(15.72±2.78)、(16.92±4.92)分,差异具有统计学意义(P<0.05)。治疗后,实验组ABC量表中的感觉评分(6.57±3.51)分、交往评分(14.44±7.34)分、运动评分(7.33±3.54)分、语言评分(10.31±5.18)分、自理评分(11.72±5.01)分均低于对照组的(8.84±4.11)、(18.77±3.81)、(10.54±6.47)、(13.62±2.82)、(14.47±4.03)分,差异具有统计学意义(P<0.05)。结论盐酸哌甲酯控释片联合感觉统合训练效果较好,可明显改善高功能孤独症谱系障碍共病注意缺陷多动障碍患儿的临床症状,值得临床推广应用。Objective To study the efficacy of methylphenidate hydrochloride controlled-release tablets alone and in combination with sensory integration training in children with high-functioning autism spectrum disorder and attention deficit hyperactivity disorder.Methods A total of 50 children with high-functioning autism spectrum disorder and attention deficit hyperactivity disorder were randomly divided into experimental group and control group,with 25 cases in each group.The control group was treated with methylphenidate hydrochloride controlled-release tablets alone,and the experimental group was combined with sensory integration training on the basis of the control group.The results of integrated visual and auditory continuous performance test(IVA-CPT),attention deficit hyperactivity disorder rating scale-Ⅳ(ADHD-RS-Ⅳ)score before and after treatment,and autism behavior checklist(ABC)score after treatment were compared between the two groups.Results After treatment,the full response control quotient(FRCQ)(109.50±24.41)and full attention quotient(FAQ)(99.41±20.66)in IVA-CPT of the experimental group were higher than(97.30±15.31)and(88.65±10.01)of the control group,and the differences were statistically significant(P<0.05).After treatment,the ADHD-RS-Ⅳscores(13.01±3.60)points and hyperactivity-impulsive symptom scores(13.49±6.31)points of the experimental group were lower than(15.72±2.78)and(16.92±4.92)points of the control group,and the differences were statistically significant(P<0.05).After treatment,the sensory score,communication score,motor score,language score and self-care score in ABC scale in the experimental group were(6.57±3.51),(14.44±7.34),(7.33±3.54),(10.31±5.18),and(11.72±5.01)points,which were lower than(8.84±4.11),(18.77±3.81),(10.54±6.47),(13.62±2.82),and(14.47±4.03)points in the control group,and the differences were statistically significant(P<0.05).Conclusion The methylphenidate hydrochloride controlled-release tablets combined with sensory integration training has good effe

关 键 词：盐酸哌甲酯控释片 感觉统合训练 注意缺陷多动障碍 孤独症 临床疗效 

分 类 号：R749.94[医药卫生—神经病学与精神病学]