胃食管反流病发病分子机制研究进展  

Research process on pathogenesis of gastroesophageal reflux disease

作　　者：亚力坤·吐尔洪 买买提·依斯热依力 克力木·阿不都热依木[1,2,3,4] Yalikun Tuerhong;Maimaiti Yisireyili;Kelimu Abudureyimu(Department of Minimally Invasive,Hernia and Abdominal Wall Surgery,Xinjiang Uygur Autonomous Region People′s Hospital,Urumqi 830001,China;Graduate School of Xinjiang Medical University,Urumqi 830054,China;Institute of Minimally Invasivel Surgery,Xinjiang Uygur Autonomous Region People′s Hospital,Urumqi 830001,China;Xinjiang Uygur Autonomous Region Clinical Research Center for Gastroesophageal Reflux Disease,Bariatric and Metabolic Surgery,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院微创,疝和腹壁外科,乌鲁木齐830001 [2]新疆医科大学研究生学院,乌鲁木齐830054 [3]新疆维吾尔自治区人民医院普外微创研究所,乌鲁木齐830001 [4]新疆维吾尔自治区胃食管反流病及减重代谢外科临床研究中心,乌鲁木齐830001

出　　处：《中国医师杂志》2022年第9期1425-1428,共4页Journal of Chinese Physician

基　　金：新疆维吾尔自治区自然科学基金(2021D01C148)。

摘　　要：胃食管反流病(GERD)是一种由于胃内容物反流到食道或口腔而引起症状或并发症的胃肠运动障碍。GERD的典型症状是胃灼热和胃内容物反流到口咽。胃灼热可放射至颈部,通常在饭后或躺卧时加重,并可通过抗酸剂缓解。反流是胃内容物回流到口腔或下咽。上腹部疼痛也可以是胃食管反流的症状,食管反流的食管外症状包括牙齿腐蚀、喉炎、咳嗽和哮喘。近年来,对GERD的分子基础的认识取得了重大进展,提示其发病机制更加复杂且涉及多因素参与。本文以GERD的分子发病机制为出发点从基因在GERD的发病发展中的作用机制、NF-κB通路在GERD中的发生发展中的作用、蛋白酶激活受体-2在GERD发病机制中的作用、5-羟色胺通路异常与GERD的联系及活性氧产生在GERD中重要的作用等五个方面总结GERD的发病机制。Gastroesophageal reflux disease(GERD)is a gastrointestinal motility disorder that results from the reflux of stomach contents into the esophagus or oral cavity,causing symptoms or complications.The typical symptoms of GERD are heartburn and regurgitation of gastric contents into the oropharynx.Heartburn is the sensation of burning or discomfort behind the sternum.Heartburn may radiate into the neck,is typically worse after meals or when in a reclining position,and may be eased by antacids.Regurgitation is the backflow of gastric contents into the mouth or hypopharynx.Epigastric pain can also be a symptom of GERD.Extraesophageal symptoms of GERD include dental erosions,laryngitis,cough,and asthma.In recent years,great progress has been made in understanding the molecular basis of GERD,suggesting that its pathogenesis is more complex and multifactorial.In this paper,the molecular pathogenesis was taken as the starting point,including the mechanism of genes in the pathogenesis and development of GERD,the mechanism of NF-κB pathway in the pathogenesis and development of GERD,the role of proteinase-activated receptor-2 in the pathogenesis of GERD,the association between abnormal serotonin pathway and GERD,and the relationship between reactive oxygen species and GERD,to summarize the pathogenesis of gastroesophageal reflux disease.

关 键 词：胃食管反流 NF-κB 受体2 蛋白酶激活 5-羟色胺 

分 类 号：R57[医药卫生—消化系统]