Na_(V)1.6通道在癫痫发病机制中的研究进展  

Research progress of Na_(V)1.6 channel in the pathogenesis of epilepsy

作　　者：杨俊婷 王昱蘅[1] 郭慧淑[2] 蔡正旭[1] YANG Junting;WANG Yuheng;GUO Huishu;CAI Zhengxu(Department of Neurology,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;Central Laboratory,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China)

机构地区：[1]大连医科大学附属第一医院神经内科,辽宁大连116011 [2]大连医科大学附属第一医院中心实验室,辽宁大连116011

出　　处：《大连医科大学学报》2022年第4期352-356,361,共6页Journal of Dalian Medical University

摘　　要：癫痫是一种常见的大脑疾病,其发病机制复杂多样,至今尚未完全明确。但随着电生理学技术的发展,越来越多的研究结果揭示了癫痫与离子通道的联系。离子通道是神经系统兴奋性产生与调节的关键因子,Na_(V)1.6作为电压门控钠通道(VGSCs)的亚型之一,其介导的持续性Na^(+)电流(I_(NaP))和复活性Na^(+)电流(I_(NaR))是神经元兴奋性的重要组成。Na_(V)1.6通道表达量的改变及基因突变引起的功能异常均在癫痫中发挥重要作用,可见Na_(V)1.6通道功能障碍是癫痫发病机制之一。通过对该通道的进一步研究有助于了解癫痫的发病机制,并找到有效的治疗方法。Epilepsy is a common brain disease,and its pathogenesis is complex and unclear.With the development of electrophysiological technology,more and more research results reveal the connection between epilepsy and ion channels.Ion channels are key factors in the generation and regulation of excitability in the nervous system.As one of the subtypes of voltagegated sodium channels(VGSCs),Na_(V)1.6 mediates persistent Na^(+)current(I_(NaP))and reactivated Na^(+)current(I_(NaR)),which is one of the important components of neuronal excitability.Changes in the expression of Na_(V)1.6 channel and functional abnormalities caused by gene mutation play an important role in epilepsy.Further research on this channel will help to understand the pathogenesis of epilepsy and find effective treatments.

关 键 词：癫痫 发病机制 Na_(V)1.6 

分 类 号：R741[医药卫生—神经病学与精神病学]