miRNA参与植物多酚改善脂代谢紊乱作用的研究进展  

Research progress of miRNA involvement in plant polyphenols in regulating lipid metabolism

作　　者：秦虹 宋子羽 郑温雅 QIN Hong;SONG Zi-yu;ZHENG Wen-ya(Dept of Nutrition and Food Hygiene,Xiangya School of Public Health,Central South University,Changsha 410078,China)

机构地区：[1]中南大学湘雅公共卫生学院营养与食品卫生学教研室,湖南长沙410078

出　　处：《中国药理学通报》2022年第10期1441-1445,共5页Chinese Pharmacological Bulletin

基　　金：湖南省自然科学基金项目(No 2020JJ5795);湖南省卫生健康委项目(No 202112021806);国家自然科学基金面上项目(No 82073556)。

摘　　要：脂代谢紊乱是诱发肥胖、2型糖尿病、非酒精性脂肪肝等慢性代谢疾病的重要危险因素。Micro RNA(miRNA)作为一类短链非编码RNA,被发现可调控脂代谢在内的多项生理功能。有研究表明,miRNA可参与植物多酚类药物单体对脂代谢的调节,该文从甘油三酯合成、脂肪酸β氧化、胆固醇流出、胆固醇酯化等多种途径对植物多酚通过miRNA改善脂代谢紊乱,维护机体脂质平衡的作用机制进行归纳总结。将为应用和开发植物多酚的药物从而改善脂代谢紊乱相关疾病提供新的思路,并为miRNA为潜在靶点的药物研发来防治脂代谢紊乱相关疾病提供理论依据。Lipid metabolism disorder is an important risk factor for obesity,type 2 diabetes mellitus,non-alcoholic fatty liver disease and other chronic metabolic diseases.Micro RNAs(miRNAs)are short stranded RNA molecules with the size of 19 to 25 nucleotides that regulate lipid metabolism,within a number of physiological functions.Studies have shown that miRNAs can participate in the regulation of lipid metabolism by polyphenolic phytochemicals.In this paper,the mechanism of plant polyphenols improving lipid metabolism disorders and maintaining lipid balance through miRNA is summarized from the synthesis of triglyceride,fatty acidβoxidation,cholesterol efflux and cholesterol esterification,aiming to provide a new thought for the application and development of plant polyphenols to improve the diseases related to lipid metabolism disorders,and offer theoretical basis for the research and development of miRNA as a potential target for the prevention and treatment of diseases related to lipid metabolism disorders.

关 键 词：MIRNA 植物多酚 脂代谢 甘油三酯合成 脂肪酸β氧化 胆固醇流出 胆固醇酯化 

分 类 号：R342.22[医药卫生—基础医学] R282.71R342.2R344R349.15