Preparation of multicore millimeter-sized spherical alginate capsules to specifically and sustainedly release fish oil  

作　　者：Lina Tao Panpan Wang Ting Zhang Mengzhen Ding Lijie Liu Ningping Tao Xichang Wang Jian Zhong 

机构地区：[1]National R&D Branch Center for Freshwater Aquatic Products Processing Technology(Shanghai),Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product Processing,Ministry of Agriculture and Rural Affairs of the People's Republic of China,Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation,College of Food Science&Technology,Shanghai Ocean University,Shanghai 201306,China

出　　处：《Food Science and Human Wellness》2023年第2期397-406,共10页食品科学与人类健康（英文）

基　　金：supported by research grants from the National Key R&D Program(2019YFD0902003)。

摘　　要：Specific and sustained release of nutrients from capsules to the gastrointestinal tract has attracted many attentions in the field of food and drug delivery.In this work,we reported a monoaxial dispersion electrospraying-ionotropic gelation technique to prepare multicore millimeter-sized spherical capsules for specific and sustained release of fish oil.The spherical capsules had diameters from 2.05 mm to 0.35 mm with the increased applied voltages.The capsules consisted of uniform(at applied voltages of≤10 k V)or nonuniform(at applied voltages of>10 k V)multicores.The obtained capsules had reasonable loading ratios(9.7%-6.3%)due to the multicore structure.In addition,the obtained capsules had specific and sustained release behaviors of fish oil into the small intestinal phase of in vitro gastrointestinal tract and small intestinal tract models.The simple monoaxial dispersion electrospraying-ionotropic gelatin technique does not involve complicated preparation formulations and polymer modification,which makes the technique has a potential application prospect for the fish oil preparations and the encapsulation of functional active substances in the field of food and drug industries.

关 键 词：Ionotropic gelation Millimeter-sized spherical capsule Monoaxial dispersion electrospraying MULTICORE Specific and sustained release 

分 类 号：TS20[轻工技术与工程—食品科学]