Advanced 4D-bioprinting technologies for brain tissue modeling and study  

作　　者：Timothy J.Esworthy Shida Miao Se-Jun Lee Xuan Zhou Haitao Cui Yi Y.Zuo Lijie Grace Zhang 

机构地区：[1]Department of Mechanical and Aerospace Engineering,The George Washington University,Washington,DC,USA [2]Department of Mechanical Engineering,University of Hawaii at Manoa,Honolulu,HI,USA [3]Department of Medicine,The George Washington University,Washington,DC,USA [4]Department of Biomedical Engineering,The George Washington University,Washington,DC,USA [5]Department of Electrical and Computer Engineering,The George Washington University,Washington,DC,USA

出　　处：《International Journal of Smart and Nano Materials》2019年第3期177-204,共28页国际智能和纳米材料杂志（英文）

基　　金：supported by NSF MME program grant#1642186;March of Dimes Foundation’s Gene Discovery and Translational Research Grant and NIH Director’s New Innovator Award 1DP2EB020549-01.

摘　　要：Although the process by which the cortical tissues of the brain fold has been the subject of considerable study and debate over the past few decades,a single mechanistic description of the phenomenon has yet to be fully accepted.Rather,two competing explanations of cortical folding have arisen in recent years;known as the axonal tension and the differential tangential expansion models.In the present review,these two models are introduced by analyzing the computational,theoretical,materials-based,and cell studies which have yielded them.Then Four-dimensional bioprinting is presented as a powerful technology which can not only be used to test both models of cortical folding de novo,but can also be used to explore the reciprocal effects that folding associated mechanical stresses may have on neural development.Therein,the fabrication of‘smart’tissue models which can accurately simulate the in vivo folding process and recapitulate physiologically relevant stresses are introduced.We also provide a general description of both cortical neurobiology as well as the cellular basis of cortical folding.Our discussion also entails an overview of both 3D and 4D bioprinting technologies,as well as a brief commentary on recent advancements in printed central nervous system tissue engineering.

关 键 词：4D bioprinting smart materials BRAIN cortical folding GYRIFICATION 

分 类 号：R73[医药卫生—肿瘤]