SARS-CoV-2辅助蛋白ORF8的功能及研究进展  

The research progress and function of SARS-CoV-2 accessory protein ORF8

作　　者：付亚男 曾凤 饶晶晶 黄艳萍 刘志新 刘龙 FU Ya′nan;ZENG Feng;RAO Jingjing;HUANG Yanping;LIU Zhixin;LIU Long(School of Basic Medical Sciences,Hubei University of Medicine,Shiyan 442000,China)

机构地区：[1]湖北医药学院基础医学院,442000

出　　处：《天津医药》2022年第10期1110-1114,共5页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(82002149);湖北省卫生健康委员会项目(WJ2021M059)。

摘　　要：新型冠状病毒(SARS-CoV-2)与2002年开始流行的冠状病毒(SARS-CoV)基因组相似,编码多种病毒蛋白。其中辅助蛋白ORF8与SARS-CoV ORF8有较低的序列同源性,且有快速进化和突变的特征,具有抑制Ⅰ型干扰素、下调主要组织相容性复合体Ⅰ(MHCⅠ)表达等功能。该文就SARS-CoV-2辅助蛋白ORF8的结构、功能及对COVID-19的诊断治疗前景进行综述。Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has a genome similar to that of the SARSCoV,which has been circulating since 2002 and encodes multiple viral proteins.The accessory protein ORF8 has low sequence homology with SARS-CoV ORF8,and has characteristics of rapid evolution and mutation.It has functions of inhibiting type Ⅰ interferon and down-regulating the expression of major histocompatibility complex Ⅰ(MHC Ⅰ).This paper reviews the structure and function of accessory protein ORF8 and the diagnostic and therapeutic prospects for COVID-19.

关 键 词：SARS病毒 免疫逃避 突变 进化 分子 新型冠状病毒 ORF8 

分 类 号：R373.1[医药卫生—病原生物学]