虚拟仿真技术在抗体工程实验教学中的应用——以PD-1人源化抗体制备为例  

Applying Virtual Simulation Technology in Experiment Teaching of Antibody Engineering:A Case Study on PD-1 Humanized Antibody Preparation

作　　者：侯景 柳海燕 刘青娥[1] 叶选怡[1] HOU Jing;LIU Haiyan;LIU Qing’e;YE Xuanyi(Faculty of Ecology,Lishui University,Lishui 323000,Zhejiang)

机构地区：[1]丽水学院生态学院,浙江丽水323000

出　　处：《丽水学院学报》2022年第5期117-122,共6页Journal of Lishui University

基　　金：教育部2020年产学合作协同育人项目“基于虚拟仿真技术构建虚实结合的抗体工程实践教学”(教高司函[2021]3号);浙江省教育厅高等教育“十三五”人才培养项目“PD-1人源化单抗的筛选、制备及鉴定虚拟仿真实验教学”(浙教办函[2019]365号);2020年省级虚拟仿真实验教学项目“甲型H1N1流感病毒裂解疫苗的生产与检定虚拟仿真实验”(浙教办函[2021]7号);丽水学院“课程思政”教育教学改革项目“抗体工程”(丽学院办[2020]39号)。

摘　　要：随着国内外新兴市场和新技术市场对生物技术药物的需求迅速增长,传统抗体工程实践教学已无法满足高校对生物、医药类专业建设的需求,而虚拟仿真技术成为传统实践教学的有益补充。根据抗体工程实验教学现状,文章首先讨论了虚拟仿真技术在抗体工程实验教学中应用的必要性;其次重点阐述采用虚拟仿真技术将PD-1人源化抗体制备的实际生产案例引入到抗体工程实验教学的内容设计和应用实践中;最后分析了抗体工程虚拟仿真实验教学的应用成效。抗体工程虚拟仿真实验教学平台在抗体工程实验中的应用是抗体技术知识更新、抗体工程实验教学的新模式,具有一定的示范意义。With the rapid growth of the demand for biotechnological drugs in emerging markets and new technology markets at home and abroad,the traditional antibody engineering practice teaching has been unable to meet the needs of the construction of biopharmaceutical specialty in universities.The virtual simulation technology has become a useful supplement to the traditional practice teaching.According to the current situation of antibody engineering experiment teaching,firstly,the necessity of applying virtual simulation technology in antibody engineering experiment teaching is discussed.Secondly,it focuses on the content design and application practice of introducing the actual production cases of PD-1 humanized antibody production into antibody engineering experiment teaching by using virtual simulation technology.Finally,the application effect of virtual simulation experiment teaching of antibody engineering is analyzed.The application of antibody engineering virtual simulation experiment teaching platform is a new model of antibody technology knowledge updating and antibody engineering experiment teaching,which has exemplary significance.

关 键 词：虚拟仿真实验 生物制药 抗体工程 实验教学 

分 类 号：G642[文化科学—高等教育学]