Autologous bone marrow mononuclear cell transplantation in patients with chronic traumatic brain injury-a clinical study  

作　　者：Alok K.Sharma Hemangi M.Sane Pooja P.Kulkarni Nandini Gokulchandran Hema Biju Prerna B.Badhe 

机构地区：[1]Department of Medical Services,NeuroGen Brain&Spine Institute,Plot 19,Sector 40,Next to Seawood Grand Central Station(W),Off Palm Beach Road,Nerul,Navi Mumbai 400706,India [2]Department Of Research&Development,NeuroGen Brain&Spine Institute,Plot 19,Sector 40,Next to Seawood Grand Central Station[W],Off Palm Beach Road,Nerul,Navi Mumbai 400706,India [3]Department of Neurorehabilitation,NeuroGen Brain&Spine Institute,Plot 19,Sector 40,Next to Seawood Grand Central Station[W],Off Palm Beach Road,Nerul,Navi Mumbai 400706,India [4]Department of Regenerative Laboratory Services,NeuroGen Brain&Spine Institute,Plot 19,Sector 40,Next to Seawood Grand Central Station[W],Off Palm Beach Road,Nerul,Navi Mumbai 400706,India

出　　处：《Cell Regeneration》2020年第1期6-16,共11页细胞再生（英文）

摘　　要：Background:Chronic Traumatic Brain Injury(TBI)is one of the common causes of longterm disability worldwide.Cell transplantation has gained attention as a prospective therapeutic option for neurotraumatic disorders like TBI.The postulated mechanism of cell transplantation which includes angiogenesis,axonal regeneration,neurogenesis and synaptic remodeling,may tackle the pathology of chronic TBI and improve overall functioning.Methods:To study the effects of cell transplantation,50 patients with chronic TBI were enrolled in an open label nonrandomized study.The intervention included intrathecal transplantation of autologous bone marrow mononuclear cells and neurorehabilitation.Mean follow up duration was 22 months.Fifteen patients underwent second dose of cell transplantation,6 months after their first intervention.Percentage analysis was performed to analyze the symptomatic improvements in the patients.Functional independence measure(FIM)was used as an outcome measure to evaluate the functional changes in the patients.Statistical tests were applied on the pre-intervention and post-intervention scores for determining the significance.Comparative Positron Emission Tomography-computed tomography(PET CT)scans were performed in 10 patients to monitor the effect of intervention on brain function.Factors such as age,multiple doses,time since injury and severity of injury were also analyzed to determine their effect on the outcome of cell transplantation.Adverse events were monitored throughout the follow up period.Results:Overall 92%patients showed improvements in symptoms such as sitting and standing balance,voluntary control,memory,oromotor skills lower limb activities,ambulation,trunk&upper limb activity,speech,posture,communication,psychological status,cognition,attention and concentration,muscle tone,coordination,activities of daily living.A statistically significant(at p≤0.05 with p-value 0)improvement was observed in the scores of FIM after intervention on the Wilcoxon signed rank test.Better outcome of the inte

关 键 词：AUTOLOGOUS Bone marrow Mononuclear cells CHRONIC Traumatic brain injury PET CT scan NEUROREHABILITATION 

分 类 号：R65[医药卫生—外科学]