The roles and activation of endocardial Notch signaling in heart regeneration  

作　　者：Huicong Li Cheng Chang Xueyu Li Ruilin Zhang 

机构地区：[1]School of Life Sciences,Fudan University,Shanghai,China [2]School of Basic Medical Sciences,Wuhan University,Wuhan,China

出　　处：《Cell Regeneration》2021年第1期27-34,共8页细胞再生（英文）

基　　金：This study was supported by National Key R&D Program of China grant 2018YFA0801000 and NSFC grant 31571492 to R.

摘　　要：As a highly conserved signaling pathway in metazoans,the Notch pathway plays important roles in embryonic development and tissue regeneration.Recently,cardiac injury and regeneration have become an increasingly popular topic for biomedical research,and Notch signaling has been shown to exert crucial functions during heart regeneration as well.In this review,we briefly summarize the molecular functions of the endocardial Notch pathway in several cardiac injury and stress models.Although there is an increase in appreciating the importance of endocardial Notch signaling in heart regeneration,the mechanism of its activation is not fully understood.This review highlights recent findings on the activation of the endocardial Notch pathway by hemodynamic blood flow change in larval zebrafish ventricle after partial ablation,a process involving primary cilia,mechanosensitive ion channel Trpv4 and mechanosensitive transcription factor Klf2.

关 键 词：Heart regeneration Notch signaling Hemodynamic alteration klf2 Primary cilium Ion channel 

分 类 号：R73[医药卫生—肿瘤]