Stem/progenitor cells in fetuses and newborns:overview of immunohistochemical markers  

作　　者：D.Fanni C.Gerosa C.Loddo M.Castagnola V.Fanos M.Zaffanello G.Faa 

机构地区：[1]Division of Pathology,University Hospital San Giovanni Di Dio,via Ospedale,54,Cagliari,Italy [2]Department of Biology,College of Science and Technology,Temple University,Phidelphia,USA [3]Neonatal Intensive Care Unit,Department of Surgical Sciences,University of Cagliari,Cagliari,Italy [4]Laboratory of Biochemistry and Metabolomics,IRCCS Fondazione Santa Lucia,Rome,Italy [5]Department of Surgical Sciences,Dentistry,Gynecology and Pediatrics,University of Verona,Piazzale Stefani,1,I-37126 Verona,Italy

出　　处：《Cell Regeneration》2021年第1期239-250,共12页细胞再生（英文）

摘　　要：Microanatomy of the vast majority of human organs at birth is characterized by marked differences as compared toadult organs, regarding their architecture and the cell types detectable at histology. In preterm neonates, thesedifferences are even more evident, due to the lower level of organ maturation and to ongoing cell differentiation.One of the most remarkable finding in preterm tissues is the presence of huge amounts of stem/progenitor cells inmultiple organs, including kidney, brain, heart, adrenals, and lungs. In other organs, such as liver, the completelydifferent burden of cell types in preterm infants is mainly related to the different function of the liver duringgestation, mainly focused on hematopoiesis, a function that is taken by bone marrow after birth. Our preliminarystudies showed that the antigens expressed by stem/progenitors differ significantly from one organ to the next.Moreover, within each developing human tissue, reactivity for different stem cell markers also changes duringgestation, according with the multiple differentiation steps encountered by each progenitor during development. Abetter knowledge of stem/progenitor cells of preterms will allow neonatologists to boost preterm organmaturation, favoring the differentiation of the multiple cells types that characterize each organ in at term neonates.

关 键 词：FETUS Immunohistochemical analysis NEWBORN Progenitor cells Stem cells 

分 类 号：R73[医药卫生—肿瘤]