体重指数对胆囊癌患者预后及生存时间的影响  

Effect of body mass index on prognosis and survival time of patients with gallbladder carcinoma

作　　者：武攀 岳学良[1] 杨森 闫一洋 赵中原 闫帅 谭飞龙 刘红山[1] WU Pan;YUE Xue-liang;YANG Sen;YAN Yi-yang;ZHAO Zhong-yuan;YAN Shuai;TAN Fei-long;LIU Hong-shan(Henan Provincial People’s Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院肝胆胰腺外科,郑州450003

出　　处：《医药论坛杂志》2022年第15期44-47,共4页Journal of Medical Forum

基　　金：河南省医学科技攻关计划省部共建项目(SB201901079);河南省医学科技攻关计划联合共建项目(LHGJ20200011)。

摘　　要：目的研究体重指数(BMI)与胆囊癌患者预后及生存时间的影响并探讨其相关性。方法收集2017—2018年在河南省人民医院行因胆囊癌行手术治疗的患者101例,根据《中国成人超重和肥胖症预防控制指南》将病人分为正常体重组(BMI<23.5 kg/m^(2),n=40)、超重组(23.5kg/m^(2)≥BMI<27.5 kg/m^(2),n=35)、肥胖组(BMI≥27.5 kg/m^(2),n=25)。比较各组的患者的临床病理的特征及生存时间,分析胆囊癌患者预后及生存时间的影响因素。结果胆囊癌患者超重组、肥胖组与正常组在淋巴结转移、远处转移中差异有统计学意义(P<0.05),肥胖组的中位生存时间显著低于正常组和超重组(χ^(2)=12.805,P<0.05),差异有统计学意义,在胆囊癌患者预后的单因素、多因素分析中淋巴结转移与BMI分组是胆囊癌患者预后及生存时间的非独立危险因素(P>0.05)。结论体重指数增高会影响胆囊癌患者的预后及生存时间,并增加肿瘤转移风险,临床中应重视肥胖对胆囊癌疾病诊治的影响。Objective To study the effect of body mass index(BMI)on prognosis and survival time of patients with gallbladder carcinoma and to explore their correlation.Methods A total of 101patients with gallbladder cancer who underwent surgery for gallbladder cancer in Henan Provincial People’s Hospital from 2017 to 2018 were collected.According to the Chinese guidelines for Prevention and Control of overweight and Obesity for Adults,the pa⁃tients were divided into normal weight group(BMI<23.5 kg/m^(2),n=40),overweight group(23.5 kg/m weight≥BMI<27.5 kg/m^(2),n=35)and obese group(BMI≥27.5 kg/m^(2),n=25).The clinicopathological features and survival time of the patients in each group were compared,and the factors affecting the prognosis were analyzed.Results There was significant difference between overweight group,obese group and normal group without lymph node metastasis and distant metastasis(P<0.05),the median survival time of obese group was significantly lower than that of normal group and overweight group(χ^(2)=12.805,P<0.05),the difference is statistically significant.In univariate and multivariate analysis of prognosis of patients with gallbladder cancer,lymph node metastasis and BMI grouping were independent risk factors for prognosis and survival time of patients with gallbladder cancer(P>0.05).Conclusion The increase of BMI will affect the prognosis and survival time of patients with gall⁃bladder cancer,and increase the risk of tumor metastasis.More attention should be paid to the effect of obesity on the diagnosis and treatment of gallbladder cancer.

关 键 词：体重指数 胆囊癌 临床病理 预后 

分 类 号：R735.8[医药卫生—肿瘤]