改良卵巢移位术与双侧卵巢切除术对宫颈癌患者性激素和并发症的影响  

Effects of modified ovarian transposition surgery and bilateral oophorectomy on sex hormones and complications in patients with cervical cancer

作　　者：李涛 阎雨萌 崔俣 LI Tao;YAN Yu-meng;CUI Yu(Department of Obstetrics and Gynecology,Yingkou Central Hospital,Yingkou 115000,China)

机构地区：[1]辽宁营口市中心医院妇产科,营口115000

出　　处：《中国肿瘤临床与康复》2022年第9期1093-1097,共5页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的 探讨改良卵巢移位术与双侧卵巢切除术对宫颈癌患者性激素和并发症的影响。方法 回顾性选取2019年1月至2020年12月间营口市中心医院收治的82例宫颈癌患者,依据手术方案不同分为移位组43例和切除组39例。移位组患者行改良卵巢移位术,切除组患者行双侧卵巢切除术,比较两组患者治疗前后卵泡刺激素(FSH)、黄体生成素(LH)、孕酮(P)和雌二醇(E2)水平,比较常见并发症、更年期临床症状调查表(Kupperman)评分、卵巢功能情况及复发情况。结果 治疗前,两组患者血清性激素指标比较,差异均无统计学意义(P>0.05)。治疗后,两组患者FSH、LH水平均高于治疗前,P和E2水平均低于治疗前,且移位组FSH和LH水平均低于切除组,P和E2水平均高于切除组,差异均有统计学意义(P<0.05)。移位组患者并发症总发生率为11.6%,切除组为23.1%,组间比较,差异无统计学意义(P>0.05)。治疗后6个月,移位组改良Kupperman评分显示,患者基本恢复正常生活,切除组患者出现不同程度的围绝经综合征。移位组Kupperman总评分低于切除组,差异有统计学意义(P<0.05)。治疗后6个月,移位组患者卵巢功能正常19例(44.2%),切除组0例;移位组患者1年内复发2例(4.6%),切除组8例(20.5%),差异均有统计学意义(P<0.05)。结论 改良卵巢移位术应用于宫颈癌患者,相对于卵巢切除术,能更好地稳定患者性激素水平,1年内疾病复发率低,改善患者预后。Objective To explore the effects of modified ovarian transposition surgery and bilateral oophorectomy on sex hormones and complications in patients with cervical cancer. Methods A retrospective analysis of the clinical data was conducted in 82 patients with cervical cancer who admitted to Yingkou Central Hospital from January 2019 to December 2020. Based on operation approaches, they were categorized into a transposition group(43 patients) and a resection group(39 patients). The transposition group underwent modified ovarian transposition and the resection group underwent bilateral oophorectomy. Follicle-stimulating hormone(FSH), luteinising hormone(LH), progesterone(P) and estradiol(E2) levels before and after treatment, common complications, Kupperman menopausal index score, ovarian function and recurrence were compared between the two groups. Results Before the treatment, there was no significant difference in serum sex hormone indicators between the two groups(P>0.05). After the treatment, FSH and LH levels increased and P and E2 levels decreased in both groups and FSH and LH levels were lower in the transposition group than in the resection group and P and E2 levels were higher in the transposition group than in the resection group(all P<0.05). The incidence of complications was 11.6% in the transposition group and 23.1% in the resection group(P>0.05). At 6 months after the treatment, modified Kupperman score showed that patients in the transposition group basically return to normal and patients in the resection group suffered perimenopausal syndrome at various degrees. The overall Kupperman score was higher in the transposition group than in the resection group(P<0.05). At 6 months after the treatment, normal ovarian function was achieved in 19 patients(44.2%) in the transposition group and one in the control group. The 1-year recurrence occurred in 2 patients(4.6%) in the transposition group and 8 patients(20.5%) in the resection group(P<0.05). Conclusion Compared with oophorectomy, modified ovarian can be

关 键 词：改良卵巢移位术 双侧卵巢切除术 宫颈肿瘤 性激素 并发症 

分 类 号：R737.3[医药卫生—肿瘤]