曲马多联合雷莫司琼对子宫肌瘤切除术患者的镇痛效果观察  

Analgesic effect of tramadol combined with ramosetron in patients undergoing myomectomy

作　　者：唐慧 黄唯 蔡玲 TANG Hui;HUANG Wei;CAI Ling(Department of Anesthesiology,Changning District Matermal and Child Health Hospital,Shanghai 200050,China)

机构地区：[1]上海市长宁区妇幼保健院麻醉科,上海200050

出　　处：《中国肿瘤临床与康复》2022年第9期1102-1105,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的 探讨曲马多联合雷莫司琼对子宫切除术患者镇痛效果、术后肠麻痹及恶心呕吐的影响。方法 选取2019年1月至2021年4月间上海市长宁区妇幼保健院行子宫肌瘤切除术治疗的102例子宫肌瘤患者为研究对象,依据随机数表法分为观察组和对照组,每组51例。对照组采用曲马多进行镇痛,观察组采用曲马多联合雷莫司琼进行镇痛,观察比较两组患者镇痛效果、术后肠麻痹及恶心呕吐的差异性。结果 拔管即刻,两组患者疼痛评分(VAS)比较,差异无统计学意义(P>0.05);术后6h、术后12h及术后24h,两组患者VAS评分均呈进行性下降,且观察组评分均低于对照组,差异均有统计学意义(均P<0.05)。相较于拔管即刻,术后6h、术后12h、术后24h两组镇静评分比较,差异无统计学意义(P>0.05)。观察组肠鸣音恢复时间、首次排气时间和恶心、呕吐发生情况均少于对照组,差异均有统计学意义(均P<0.05)。两组头晕、嗜睡和过敏发生情况比较,差异无统计学意义(P>0.05)。结论 子宫肌瘤切除术患者采用曲马多联合雷莫司琼做术后镇痛处理,可显著降低患者疼痛感,且不会影响镇静效果,并缩短术后肠麻痹时间,减少恶心呕吐的发生。Objective To investigate the analgesic effect of tramadol combined with ramosetron and the effects on postoperative intestinal paralysis and nausea and vomiting in patients undergoing myomectomy. Methods A total of 102 patients undergoing myomectomy were selected at Shanghai Changning District Maternal and Child Health Hospital from January 2019 to April 2021. Using the random number table method, they were divided into an observation group and a control group with 51 patients in each group. The observation group received tramadol combined with ramosetron as analgesics and the control group received tramadol alone. Differences in analgesia, postoperative intestinal paralysis and nausea and vomiting were observed and compared between the two groups. Results Immediately after extubation, there was no significant difference in visual analogue scale(VAS) pain rating scale scores between the two groups(P>0.05). VAS scores in the two groups decreased progressively at 6 h, 12 h, and 24 h after the operation, and the scores were significantly lower in the observation group than in the control group(all P<0.05). Compared with the immediately after extubation, Ramsay sedation scale scores of the two groups decreased progressively at 6 h, 12 h, and 24 h after the operation, but there was no significant difference between the two groups(P>0.05). Time to recovery of bowel sounds and time to postoperative exhaust was significantly shorter in the observation group than in the control group(all P<0.05). The incidence of nausea and vomiting was significantly less in the observation group than in the control group(P<0.05). There was no significant difference in the incidence of dizziness, drowsiness, and allergies between the two groups(P>0.05). Conclusion The use of tramadol combined with ramosetron for postoperative analgesia in patients undergoing uterine fibroids surgery can significantly reduce the patient’s pain without affecting the sedation effect, and can shorten the postoperative intestinal paralysis time and reduce th

关 键 词：曲马多 雷莫司琼 子宫肌瘤切除术 镇痛效果 术后肠麻痹 恶心呕吐 

分 类 号：R737.33[医药卫生—肿瘤]