25-羟维生素D诊断弥漫性大B细胞淋巴瘤患者的临床特征及预后关系  

Clinical features and prognosis of biological 25(OH)D in patients with diffuse large B-cell lymphoma

作　　者：张荣[1] 任天红[1] ZHANG Rong;REN Tianhong(Department of Clinical Laboratory,Shijiazhuang Third Hospital,Shijiazhuang,050001,China)

机构地区：[1]石家庄市第三医院检验科,石家庄050001

出　　处：《临床血液学杂志》2022年第8期556-559,共4页Journal of Clinical Hematology

摘　　要：目的探讨可利用生物25-羟维生素D[25(OH)D]水平与弥漫性大B细胞淋巴瘤(DLBCL)患者临床特征及预后的关系。方法收集2017年3月至2019年5月收治的诊断为DLBCL患者124例作为DLBCL组,另选择同时期进行健康体检且结果正常者39例作为对照组。检测2组25(OH)D水平,分析患者一般临床资料和相关实验室检测指标,分析25(OH)D水平与患者临床病理特征,Kaplan-Meier分析法分析25(OH)D水平与患者累积生存时间的关系,Cox比例风险回归模型分析患者预后的独立危险因素。结果DLBCL组患者25(OH)D水平明显低于对照组;25(OH)D水平与DLBCL患者年龄、肿瘤分期、乳酸脱氢酶、肝功能、靶器官受损和B症状有关;25(OH)D水平<18.36 ng/mL的累积生存时间明显小于25(OH)D水平≥18.36 ng/mL的患者(P<0.05);Cox分析发现Ann Arbor分期、25(OH)D和年龄是DLBCL患者预后的独立危险因素。结论DLBCL患者体内25(OH)D水平明显低于对照组,25(OH)D水平与患者临床病理特征具有一定的相关性,并且是患者预后的独立危险因素,值得临床关注。Objection To investigate the relationship between available biological 25(OH)D level and clinical characteristics and prognosis of patients with newly diagnosed diffuse large B-cell lymphoma(DLBCL).Methods A total of 124 patients with newly diagnosed DLBCL treated in our hospital from March 2017 to May 2019 were collected as DLBCL group.A total of 39 patients with normal physical examination results in our hospital at the same time were selected as the control group.25(OH)D levels were detected in both groups.The general clinical data and related laboratory test indexes of patients were analyzed.The relationship between 25(OH)D level and clinicopathological characteristics was analyzed.Kaplan-Meier analysis was used to analyze the relationship between 25(OH)D level and cumulative survival time.Cox proportional hazards regression model was used to analyze the independent risk factors of prognosis.Results The level of 25(OH)D in DLBCL group was significantly lower than that in healthy control group.The level of 25(OH)D was related to age,tumor stage,lactate dehydrogenase,liver function,target organ damage and B symptoms in patients with DLBCL.The cumulative survival time of patients with 25(OH)D level<18.36 ng/mL was significantly shorter than that of patients with 25(OH)D level≥18.36 ng/mL(P<0.05).Cox analysis showed that Ann Arbor stage,25(OH)D and age were independent risk factors for the prognosis of DLBCL patients.Conclusion The level of 25(OH)D in patients with DLBCL was significantly lower than that in healthy controls.The level of 25(OH)D had a certain correlation with the clinicopathological features of patients.It may be an independent risk factor for the prognosis of patients,which should deserve clinical attention.

关 键 词：25-羟维生素D 弥漫性大B细胞淋巴瘤 临床特征 预后 

分 类 号：R733.4[医药卫生—肿瘤]