基因编辑猪用于急性肝衰竭治疗的路径探讨  

The discussion on the Genetically Modified Pigs for the treatment of acute liver failure

作　　者：淮国丽 杜嘉祥 潘登科 Huai Guoli;Du Jiaxiang;Pan Dengke(Affiliated Hospital of University of Electronic Science and Technology of China,Sichuan Academy of Medical Sciences,Sichuan Provincial People’s Hospital,Sichuan Key Laboratory of Clinical Immunological Translational Medicine,Chengdu 610072,China;Chengdu Sino-Clone Organ Biotechnology,Co.,Ltd.,Chengdu 610094,China)

机构地区：[1]电子科技大学附属医院,四川省医学科学院·四川省人民医院,临床免疫转化医学四川省重点实验室,成都610072 [2]成都中科奥格生物科技有限公司,成都610094

出　　处：《临床肝胆病杂志》2022年第10期2214-2218,共5页Journal of Clinical Hepatology

基　　金：四川省科技计划项目(重点研发项目)(2021YFS0008)。

摘　　要：目前,我国肝移植需求巨大,然而却面临供体器官极度短缺的限制。异种(猪)肝移植是有望成为缓解供体紧缺的一个潜在途径。肝脏是具有合成功能的解毒器官,当使用基因编辑猪作为供体时,面临着需要克服免疫排斥和解决生理功能不匹配的双重问题。因此,从抑制固有免疫反应出发可以更好地减轻异种肝移植的免疫排斥。此外,利用人源化细胞肝脏的嵌合体可能解决生理功能不匹配的问题。随着基因编辑技术的发展,获得多基因编辑猪和嵌合体已成为可能。因此,从上述两方面着手探索和研究,有望解决异种肝移植目前存在的问题,从而推动异种肝移植领域进一步发展。Liver transplants are in huge demand in China,but facing the problem of extreme shortage of donor organs.Xenogeneic(pig) liver transplantation may be a potential way to alleviate the shortage of donors.The liver is a detoxifying organ with synthetic functions,and when genetically modified pigs are used as donors,it faces the dual problem of overcoming immune rejection and resolving physiological function mismatches.Therefore,suppressing the innate immune response can better alleviate the immune rejection of xenotransplantation.In addition,the use of chimeras of humanized cell livers may resolve the problem of physiological function mismatch.Moreover,with the development of gene editing technology,it has become possible to obtain multiple gene edited pigs and chimeras.Therefore,exploring and researching from these two aspects will hopefully solve the current problems of liver xenotransplantation and promote the further development of the field of liver xenotransplantation.

关 键 词：肝移植 基因编辑 嵌合体 猪 

分 类 号：R575.3[医药卫生—消化系统]