肝纤维化发生机制及其中药逆转治疗的研究进展  

Recent research progress and mechanisms on Traditional Chinese Medicine reversal therapy of liver fibrosis

作　　者：刘世恒 赵素贤[1] 张玉果[1] LIU Shiheng;ZHAO Suxian;ZHANG Yuguo(Department of Traditional and Western Medical Hepatology,The Third Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第三医院中西医结合肝病科,石家庄050051

出　　处：《临床肝胆病杂志》2022年第10期2373-2377,共5页Journal of Clinical Hepatology

基　　金：河北省医学适用技术跟踪项目(G2018041)。

摘　　要：肝纤维化是指在各种病因作用下,肝星状细胞被激活,分泌大量的细胞外基质,最终导致肝脏纤维化。早期逆转肝纤维化可以阻止疾病进一步发展,减少终末期肝病和肝癌的发生,本文分别介绍了肝血窦内皮细胞(LSEC)、Notch信号通路、YAP/TAZ信号通路、细胞自噬在逆转肝纤维化方面的作用机制,并列举其各自机制下抗肝纤维化的中药治疗研究进展,以期为逆转肝纤维化提供新的研究思路及中药治疗方法。Liver fibrosis occurs due to damages caused by liver diseases of various etiologies and activation of hepatic stellate cells,leading to the repairing and damaging cycle by secreting a large amount of extracellular matrix and formation of fibrosis tissues in the liver.Early reversal of this process could prevent further development and progression of the disease,which may reduce incidence of the end-stage liver disease and even liver cancer.This review summarized and discussed recent advancements and mechanisms of liver sinusoidal endothelial cells,Notch signaling pathway,YAP/TAZ signaling pathway,and autophagy in regulation of liver fibrosis and then enumerated the Traditional Chinese Medicine in reversal of liver fibrosis process and the underlying molecular mechanisms.It expects to provide novel approaches and research ideas for future control of liver fibrosis using Traditional Chinese Medicine.

关 键 词：肝硬化 肝星状细胞 中草药 

分 类 号：R575.2[医药卫生—消化系统]