人工肝治疗的抗凝剂应用进展及选择策略  

Anticoagulants for artificial liver support therapy:Application advances and selection strategies

作　　者：马元吉[1] 杜凌遥 白浪[1] 唐红[1] MA Yuanji;DU Lingyao;BAI Lang;TANG Hong(Center of Infectious Diseases,West China Hospital of Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院感染性疾病中心,成都610041

出　　处：《临床肝胆病杂志》2022年第10期2396-2401,共6页Journal of Clinical Hepatology

基　　金：四川大学华西医院学科卓越发展1·3·5工程项目(ZYGD20009,ZYJC21014)。

摘　　要：凝血功能异常是肝衰竭的特征之一,患者体内的凝血功能趋于不稳定且脆弱的“再平衡”状态,易受内外因素影响而被打破。人工肝治疗肝衰竭时常需要使用抗凝剂,这可能打破“再平衡”,导致出血事件发生。本文综述了肝衰竭的凝血状态评估方法、可用抗凝剂的特点及其在人工肝治疗中的应用进展,并结合四川大学华西医院的选用经验,探讨人工肝治疗的抗凝管理与选择策略。Coagulation disorder is one of the characteristics of liver failure,leading to an unstable and vulnerable “rebalance” state of coagulation function,which may be easily broken by internal or external factors.Anticoagulants are often required during artificial liver support therapy for patients with liver failure,which may break the “rebalance” state and result in bleeding events.This article reviews the methods for evaluating coagulation status in liver failure,the features of available anticoagulants,and the advances in the application of such anticoagulants in artificial liver support therapy and discusses the anticoagulation management and selection strategy for artificial liver support therapy with reference to the selection experience of West China Hospital of Sichuan University.

关 键 词：肝功能衰竭 肝 人工 抗凝药 治疗学 

分 类 号：R575.3[医药卫生—消化系统]