斑蝥酸钠维生素B_(6)联合化疗治疗肺鳞癌的临床观察  

Clinical observation of sodium cantharidate vitamin B_(6) injection combined with chemotherapy in the treatment of lung squamous cell carcinoma

作　　者：罗燕 包中会 蒋义[1] 姚岚 倪燕侠 黄琴 李少林[2] 任洪波[1] 黄碧有[1] LUO Yan;BAO Zhonghui;JIANG Yi;YAO Lan;NI Yanxia;HUANG Qin;LI Shaolin;REN Hongbo;HUANG Biyou(Department of Oncology,Chongqing Banan Second People’s Hospital,Chongqing 400054,China;Teaching and Research Section of Oncology,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆市巴南区第二人民医院肿瘤科,400054 [2]重庆医科大学肿瘤学教研室,400016

出　　处：《重庆医学》2022年第19期3284-3288,共5页Chongqing medicine

基　　金：重庆市重点疾病防治技术攻关课题(2019ZX002)。

摘　　要：目的观察斑蝥酸钠维生素B_(6)注射液联合化疗对晚期肺鳞癌患者体内D-二聚体、鳞癌相关抗原(SCC-Ag)、癌胚抗原(CEA)水平及近期疗效的影响。方法选取2019年10月至2021年5月就诊于巴南区第二人民医院的100例晚期肺鳞癌患者,采用随机数字表法将患者分为两组,各50例。对照组给予紫杉醇联合顺铂(TP)化疗方案,观察组给予相同化疗方案并加用斑蝥酸钠维生素B_(6)注射液,两组均化疗6个周期。所有患者在第1次化疗前1 d及最后1次化疗后1 d采集外周血检测血浆D-二聚体及血清SCC-Ag、CEA水平并比较组间差异,同时比较两组近期疗效、不良反应发生情况及生活质量测定量表(FACT-L)评分。结果化疗后两组不同TNM分期患者血浆D-二聚体水平均较化疗前下降,差异有统计学意义(P<0.05);化疗后,两组患者血浆D-二聚体及血清SCC-Ag、CEA水平均下降(P<0.05),且观察组均低于对照组(P<0.05);化疗后,观察组总稳定率(DCR)与总有效率(ORR)略高于对照组(82.0%vs.70.0%,32.0%vs.26.0%,P>0.05);两组红细胞减少、血压降低、腹痛腹泻、恶心呕吐、神经毒性、关节肌肉疼痛发生率无明显差异(P>0.05),观察组白细胞减少、中性粒细胞减少发生率低于对照组(P<0.05);化疗后观察组FACT-L各维度评分高于对照组(P<0.05)。结论斑蝥酸钠维生素B_(6)注射液联合化疗可在一定程度上改善晚期肺鳞癌患者的近期疗效。Objective To observe the effect of sodium cantharidate vitamin B_(6) injection combined with chemotherapy on the levels of D-dimer,squamous cell carcinoma-related antigen(SCC-Ag)and carcino-embryonic antigen(CEA),and short term efficacy in the patients with advanced lung squamous cell carcinoma.Methods A total of 100 patients with advanced lung squamous cell carcinoma in the Banan District Second People’s Hospital from October 2019 to May 2021 were selected and divided into the two groups according to the random number table method,50 cases in each group.The control group was treated with the chemotherapy scheme of paclitaxel combining cisplatin(TP),while the observation group was given the same chemotherapeutic scheme,and sodium cantharidate vitamin B_(6) injection was added.Both groups received 6 cycles of chemotherapy.Peripheral blood of all cases were collected to test plasma D-dimer,SCC-Ag and CEA levels on 1 d before the first chemotherapy and on 1 d after the last chemotherapy,and the differences between the two groups were compared.At the same time,the short term efficacy,occurrence of adverse reactions and scores of quality of life measurement scale(FACT-L)were compared between the two groups.Results The plasma D-dimer levels after chemotherapy in the two groups with different TNM stages were decreased compared with those before chemotherapy,and the differences were statistically significant(P<0.05).After the chemotherapy,the plasma level of D-dimer,serum levels of SCC-Ag and CEA in both groups were decreased(P<0.05),moreover,the the plasma level of D-dimer,serum levels of SCC-Ag and CEA in the observation group were lower than those in the control group(P<0.05).The disease control rate(DCR)and overall response rate(ORR)after chemotherapy in the observation group were slightly higher than those in the control group(82.0%vs.70.0%,32.0%vs.26.0%,P>0.05).There was no significant difference in the incidence rates of erythropenia,blood pressure reduction,abdominal pain and diarrhea,nausea and vomiting,neurot

关 键 词：肺鳞癌 斑蝥酸钠维生素B_(6) 联合化疗 D-二聚体 鳞癌相关抗原 癌胚抗原 

分 类 号：R734.2[医药卫生—肿瘤]